2015
Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus.
Romerowicz-Misielak M, Oren D, Sowa-Kucma M, Tabecka-Lonczynska A, Gilun P, Stefanczyk-Krzymowska S, Koziorowski M. Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus. Journal Of Physiology And Pharmacology 2015, 66: 505-14. PMID: 26348075.Peer-Reviewed Original ResearchConceptsOphthalmic venous bloodVenous bloodNocturnal melatonin riseMelatonin levelsMelatonin riseWinter seasonal affective disorderNocturnal melatonin peakSeasonal affective disorderHour infusionCavernous sinusVenous sinusesNon-physiological changesAutologous blood plasmaAffective disordersSynthesis of melatoninBright light effectsBloodAANAT protein levelsMelatonin peakProtein levelsAcute impactSinusTreatmentBlood plasmaParallel changes
2013
SAD and the Not-So-Single Photoreceptors
Oren DA, Koziorowski M, Desan PH. SAD and the Not-So-Single Photoreceptors. American Journal Of Psychiatry 2013, 170: 1403-1412. PMID: 23929223, DOI: 10.1176/appi.ajp.2013.13010111.Peer-Reviewed Original ResearchConceptsMolecular mechanismsSeasonal affective disorderCircannual regulationCritical regulatorTetrapyrrole pigmentsDevelopment of therapiesRole of rodsInfluence of lightPhotoreceptorsCone photoreceptorsLight treatmentAntidepressant effectsPhysiologyAnimal modelsAffective disordersRecent studiesSingle photoreceptorsPhototransductionRegulatorDisordersRegulationMechanismGasotransmitterRolePigments
2001
Is Seasonal Affective Disorder a Disorder of Circadian Rhythms?
Desan P, Oren D. Is Seasonal Affective Disorder a Disorder of Circadian Rhythms? CNS Spectrums 2001, 6: 487-501. PMID: 15744212, DOI: 10.1017/s1092852900008038.Peer-Reviewed Original Research
1997
Effects of Meta-chlorophenylpiperazine Infusions in Patients With Seasonal Affective Disorder and Healthy Control Subjects: Diurnal Responses and Nocturnal Regulatory Mechanisms
Schwartz P, Murphy D, Wehr T, Garcia-Borreguero D, Oren D, Moul D, Ozaki N, Snelbaker A, Rosenthal N. Effects of Meta-chlorophenylpiperazine Infusions in Patients With Seasonal Affective Disorder and Healthy Control Subjects: Diurnal Responses and Nocturnal Regulatory Mechanisms. JAMA Psychiatry 1997, 54: 375-385. PMID: 9107154, DOI: 10.1001/archpsyc.1997.01830160103013.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderHealthy control subjectsGrowth hormone concentrationsControl subjectsNocturnal core temperatureDepressed patientsHormone concentrationsNervous systemAffective disordersCore temperatureMean growth hormone concentrationWinter depressionSympathetic nervous systemBrain serotonergic systemCentral nervous systemSignificant reductionBright light treatmentUniform abnormalityNorepinephrine responseNorepinephrine concentrationsSerotonin transmissionSelf-Rating ScaleAdrenal axisSerotonergic agentsDepression ratingsGender Differences in Depression.
Blehar M, Oren D. Gender Differences in Depression. Medscape Journal Of Medicine 1997, 2: 3. PMID: 9746677.Peer-Reviewed Original Research
1996
Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder
Oren D, Levendosky A, Kasper S, Duncan C, Rosenthal N. Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder. Biological Psychiatry 1996, 39: 157-170. PMID: 8837977, DOI: 10.1016/0006-3223(95)00079-8.Peer-Reviewed Original Research
1995
The phototherapy light visor: more to it than meets the eye
Teicher M, Glod C, Oren D, Schwartz P, Luetke C, Brown C, Rosenthal N. The phototherapy light visor: more to it than meets the eye. American Journal Of Psychiatry 1995, 152: 1197-1202. PMID: 7625470, DOI: 10.1176/ajp.152.8.1197.Peer-Reviewed Original ResearchConceptsAtypical depressive symptomsLight visorDepressive symptomsHamilton Depression Scale scoresHamilton Depression Rating ScaleBaseline depression scoresDepression Rating ScaleDepression Scale scoresFull clinical responseModerate response rateSeasonal affective disorderDim red lightClinical responseTherapeutic responseTreatment periodEffective treatmentDepression scoresPatientsResponse rateScale scoreAffective disordersRating ScaleBright white lightSignificant differencesSymptoms
1994
1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: Effects of light
Oren D, Schulkin J, Rosenthal N. 1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: Effects of light. Psychopharmacology 1994, 116: 515-516. PMID: 7701056, DOI: 10.1007/bf02247486.Peer-Reviewed Original ResearchA controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder
Oren D, Teicher M, Schwartz P, Glod C, Turner E, Ito Y, Sedway J, Rosenthal N, Wehr T. A controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder. Journal Of Affective Disorders 1994, 32: 197-200. PMID: 7852661, DOI: 10.1016/0165-0327(94)90018-3.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderAffective disordersEffective short-term treatmentWeekly outpatient visitsShort-term treatmentSIGH-SAD scoresPlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodEffective treatmentSame scheduleVitamin B12SAD patientsSignificant differencesTreatmentPatientsWeeksDisordersCyanocobalaminRandom assignmentPlaceboTrialsVisitsPlatelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder
Ozaki N, Rosenthal N, Mazzola P, Chiueh C, Hardin T, Garcia-Borreguero D, Schwartz P, Turner E, Oren D, Murphy D. Platelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder. Biological Psychiatry 1994, 36: 458-466. PMID: 7811842, DOI: 10.1016/0006-3223(94)90641-6.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderSAD patientsAffective disordersBrain serotonergic systemSerotonergic measuresSerotonergic abnormalitiesSerotonergic functionDensity-dependent subpopulationsPlatelet turnoverSerotonergic systemPatientsReceptor functionNeurotransmitter aminesTherapy conditionsHigher BmaxLight plateletsPlateletsDisordersPresent studyHeavy plateletsCa2SerotoninA Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder
OREN D, MOUL D, SCHWARTZ P, WEHR T, ROSENTHAL N. A Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder. Journal Of Clinical Psychopharmacology 1994, 14: 196-200. PMID: 8027416, DOI: 10.1097/00004714-199406000-00007.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderDopaminergic deficiencyAffective disordersItem Hamilton Rating ScaleEfficacy of levodopaUse of levodopaWeekly outpatient visitsHamilton Rating ScalePlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodRate of responseDepression scoresPatientsLevodopaPlaceboCarbidopaRating ScaleIdentical scheduleSAD patientsTreatmentWeeksDisordersExposure to ambient light in patients with winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Brown C, Yamada E, Rosenthal N. Exposure to ambient light in patients with winter seasonal affective disorder. American Journal Of Psychiatry 1994, 151: 591-593. PMID: 8147459, DOI: 10.1176/ajp.151.4.591.Peer-Reviewed Original ResearchConceptsWinter seasonal affective disorderSeasonal affective disorderAffective disordersSeverity of depressionNormal comparison subjectsMorning light exposureNormal subjectsComparison subjectsGreater severityPatientsDepressionDisordersExposure profilesSeverityExposureLight exposureSubjectsShort photoperiodOutpatientsLight monitorWeeksEFFECTS OF LIGHT ON T‐CELLS IN HIV‐INFECTED SUBJECTS ARE NOT DEPENDENT ON HISTORY OF SEASONAL AFFECTIVE DISORDER
Rosenthal N, Brown C, Oren D, Galetto G, Schwartz P, Malley J. EFFECTS OF LIGHT ON T‐CELLS IN HIV‐INFECTED SUBJECTS ARE NOT DEPENDENT ON HISTORY OF SEASONAL AFFECTIVE DISORDER. Photochemistry And Photobiology 1994, 59: 314-319. PMID: 7912442, DOI: 10.1111/j.1751-1097.1994.tb05040.x.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderSuppressor T-cell countsSignificant mood improvementPotential therapeutic valuePlasma cortisol levelsCD8 levelsHigher CD4Treatment modalitiesT cellsLight therapyCortisol levelsCrossover designAffective disordersCell countHIVTherapeutic valueMood improvementBright light conditionsSignificant differencesTreatment conditionsHigher cell countsDisordersSubjectsVisible red lightCountHigh titers of anti‐epstein‐barr virus DNA polymerase are found in patients with severe fatiguing illness
Natelson B, Ye N, Moul D, Jenkins F, Oren D, Tapp W, Cheng Y. High titers of anti‐epstein‐barr virus DNA polymerase are found in patients with severe fatiguing illness. Journal Of Medical Virology 1994, 42: 42-46. PMID: 8308519, DOI: 10.1002/jmv.1890420109.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeEpstein-Barr virusEBV DNA polymeraseSeasonal affective disorderAbnormal testsFatiguing illnessesSAD patientsSubset of patientsAbnormal titersCFS patientsSymptomatic patientsFatigue syndromePatient groupTreatment trialsHealthy controlsPatientsNormal rangeAffective disordersDisease severityUseful markerHigh titersAge rangeSocioeconomic classAntibodiesIllness
1993
Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder
Ozaki N, Rosenthal N, Moul D, Schwartz P, Oren D. Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder. Psychiatry Research 1993, 49: 99-107. PMID: 8153191, DOI: 10.1016/0165-1781(93)90098-2.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderControl subjectsLight therapyEOG ratiosSAD patientsAffective disordersEffect of phototherapyNormal control subjectsWinter seasonal affective disorderRetinal abnormalitiesPatientsConfounding factorsEOG testingTherapyDisordersSubjectsTest variabilityOutpatientsAbnormalitiesPhototherapySpontaneous eye blink rate in winter seasonal affective disorder
Barbato G, Moul D, Schwartz P, Rosenthal N, Oren D. Spontaneous eye blink rate in winter seasonal affective disorder. Psychiatry Research 1993, 47: 79-85. PMID: 8516420, DOI: 10.1016/0165-1781(93)90057-n.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderNormal control subjectsSpontaneous eye blink rateWinter seasonal affective disorderEye blink rateControl subjectsLight therapyBlink rateAffective disordersPremenopausal female subjectsSAD patientsDrug-free patientsElevated blink ratePatientsBiological markersFemale subjectsSignificant decreaseSignificant differencesTherapyDisordersSignificant changesPossible linkSubjectsTreatmentExploratory analysisSide effects of light therapy in seasonal affective disorder
Levitt A, Joffe R, Moul D, Lam R, Teicher M, Lebegue B, Murray M, Oren D, Schwartz P, Buchanan A. Side effects of light therapy in seasonal affective disorder. American Journal Of Psychiatry 1993, 150: 650-652. PMID: 8465886, DOI: 10.1176/ajp.150.4.650.Peer-Reviewed Original ResearchConceptsSide effectsSeasonal affective disorderLight therapyAffective disordersCommon symptomsTherapyDisordersA Multicenter Study of the Light Visor for Seasonal Affective Disorder: No Difference in Efficacy Found Between Two Different Intensities
Rosenthal N, Moul D, Hellekson C, Oren D, Frank A, Brainard G, Murray M, Wehr T. A Multicenter Study of the Light Visor for Seasonal Affective Disorder: No Difference in Efficacy Found Between Two Different Intensities. Neuropsychopharmacology 1993, 8: 151-160. PMID: 8471127, DOI: 10.1038/npp.1993.17.Peer-Reviewed Original ResearchAn investigation of ophthalmic function in winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Alexander J, Yatnada E, Rosenthal N. An investigation of ophthalmic function in winter seasonal affective disorder. Depression 1993, 1: 29-37. DOI: 10.1002/depr.3050010107.Peer-Reviewed Original ResearchSeasonal affective disorderWinter seasonal affective disorderAffective disordersFarnsworth-Munsell 100 hue testFunction testsIntraocular pressurePattern electroretinogramPupillary sizeLight therapyApplanation tonometerNormal controlsVisual functioningP100 componentB-wave componentHue testOphthalmic functionNeurological pathwaysOphthalmic defectsSignificant differencesPatientsDark adaptationWiley-LissColor visionDisordersLittle evidenceLight visor treament for seasonal affective disorder: A multicenter study
Joffe R, Moul D, Lam R, Levitt A, Teicher M, Lebegue B, Oren D, Buchanan A, Glod C, Murray M, Brown J, Schwartz P. Light visor treament for seasonal affective disorder: A multicenter study. Psychiatry Research 1993, 46: 29-39. PMID: 8464953, DOI: 10.1016/0165-1781(93)90005-2.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderAntidepressant responseLight therapyAffective disordersTreatment of SADSeverity of depressionAntidepressant actionAntidepressant efficacyMulticenter studyMedication statusNonspecific effectsSimilar frequencySignificant differencesTherapyParallel designDisordersTreatmentPrevious studies