2017
Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?
Henderson D, Huebner C, Markowitz M, Taube N, Harvanek ZM, Jakob U, Knoefler D. Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin? Redox Biology 2017, 14: 386-390. PMID: 29055282, PMCID: PMC5647470, DOI: 10.1016/j.redox.2017.10.003.Peer-Reviewed Original ResearchConceptsC. elegansC. elegans larvaeRedox stateVivo redox stateReduced redox statePoikilothermic organismsDevelopmental temperatureLifespan extensionRedox statusMechanistic underpinningsBeneficial long-term consequencesElegansExpression levelsOrganismsVivo redox statusWormsRedox levelsCaenorhabditisLifespanPeroxiredoxinsGrowth temperatureLarvaeAnimalsUpregulationEffect of temperature
2016
A computational approach to studying ageing at the individual level
Harvanek ZM, Mourão MA, Schnell S, Pletcher SD. A computational approach to studying ageing at the individual level. Proceedings Of The Royal Society B 2016, 283: 20152346. PMID: 26865300, PMCID: PMC4760160, DOI: 10.1098/rspb.2015.2346.Peer-Reviewed Original Research
2014
Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling
Waterson MJ, Chung BY, Harvanek ZM, Ostojic I, Alcedo J, Pletcher SD. Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 8137-8142. PMID: 24821805, PMCID: PMC4050545, DOI: 10.1073/pnas.1315461111.Peer-Reviewed Original ResearchConceptsMetabolic homeostasisAdipokinetic hormone signalingDrosophila lifespanHormone signalingAKH receptorMutant effectsMetabolic shiftPhysiological homeostasisHealthy lifespanMetabolic waterWater availabilityHomeostasisAKHGustatory systemLifespanGustatory signalsInternal lipidsCentral nervous system integrationEndocrine systemTaxaSensory regulationLong-term healthWater storesSignalingPhysiology
2013
Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward
Gendron CM, Kuo TH, Harvanek ZM, Chung BY, Yew JY, Dierick HA, Pletcher SD. Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward. Science 2013, 343: 544-548. PMID: 24292624, PMCID: PMC4042187, DOI: 10.1126/science.1243339.Peer-Reviewed Original ResearchConceptsDrosophila life spanMale fruit fliesRNA sequencing experimentsLife spanDrosophila melanogasterFemale sexual pheromoneGustatory receptorsFruit flyPheromone perceptionSequencing experimentsNeuropeptide FMolecular processesSexual pheromonesPheromone effectsPhysiologyFat storesMelanogasterTaxaSensory perceptionMatingFliesStarvationPheromoneNeuronsReceptors