2024
Childhood adversity, accelerated GrimAge, and associated health consequences
Harvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 47: 913-926. PMID: 38762606, PMCID: PMC11365810, DOI: 10.1007/s10865-024-00496-0.Peer-Reviewed Original ResearchBody mass indexChildhood Trauma QuestionnaireGrimAge accelerationEarly life stressChildhood adversityAssociated with higher body mass indexCross-sectional cohort of adultsMetabolic healthEffect of body mass indexHigher body mass indexPhysical health problemsLife stressCohort of adultsAssociated health consequencesEffects of early life stressMetabolic health effectsModerating effect of body mass indexChildhood Trauma Questionnaire subscalesCross-sectional cohortCardiometabolic healthAccelerated GrimAgeCardiometabolic diseasesMedical illnessHealth consequencesMass index
2021
Psychological and biological resilience modulates the effects of stress on epigenetic aging
Harvanek ZM, Fogelman N, Xu K, Sinha R. Psychological and biological resilience modulates the effects of stress on epigenetic aging. Translational Psychiatry 2021, 11: 601. PMID: 34839356, PMCID: PMC8627511, DOI: 10.1038/s41398-021-01735-7.Peer-Reviewed Original ResearchConceptsEmotion regulationResilience factorsCumulative stressWorse emotion regulationPoor emotion regulationPsychological resilience factorsNegative long-term health consequencesCommunity sampleEffects of stressBiological age accelerationPhysical outcomesMore stressBehavioral factorsChronic stressGrimAge accelerationHealth consequencesStress physiologyLong-term health consequencesEpigenetic agingPhysiologic measuresHealthy populationFinal modelAge accelerationAgingRelationship