2021
The immune system and autism spectrum disorder: association and therapeutic challenges
Heidari A, Rostam–Abadi Y, Rezaei N. The immune system and autism spectrum disorder: association and therapeutic challenges. Acta Neurobiologiae Experimentalis 2021, 81: 249-263. PMID: 34672295, DOI: 10.21307/ane-2021-023.Peer-Reviewed Original ResearchConceptsCentral nervous systemPlasma levels of pro-inflammatory cytokinesPrevalence of autoimmune disordersImmune systemLevels of pro-inflammatory cytokinesFirst-degree family membersAutism spectrum disorderPro-inflammatory cytokinesAnti-inflammatory drugsInnate immune systemDevelopment of autism spectrum disorderAutoimmune involvementDefinitive treatmentAutoimmune processAutoimmune disordersImmunological factorsPlasma levelsGut-brain axisTriggering inflammationASD patientsHighest prevalenceNervous systemPathogenesisASD pathogenesisGenetic factors
2020
Autism spectrum disorders and natural killer cells: a review on pathogenesis and treatment
Meimand S, Rostam-Abadi Y, Rezaei N. Autism spectrum disorders and natural killer cells: a review on pathogenesis and treatment. Expert Review Of Clinical Immunology 2020, 17: 27-35. PMID: 33191807, DOI: 10.1080/1744666x.2020.1850273.Peer-Reviewed Original ResearchConceptsNK cellsNatural killer (NK) cellsReceptors of NK cellsImmune systemNK cell dysfunctionNatural killer cellsPathogenesis of autism spectrum disorderNeurodevelopmental disordersImproper immune responsesInnate immune systemImmune abnormalitiesImmune therapyImmune dysregulationKiller cellsAutism spectrum disorderTreatment optionsImmune regulationCell dysfunctionImmune responseImmune functionCytotoxic featuresSpectrum disorderEarly-onset impairmentDisordersPathogenesis