2005
A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo
Zhou W, Wu J, Wu Q, Wang J, Zhou Y, Zhou R, He P, Li X, Yang Y, Zhang Y, Li Y, Zuo J. A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo. Acta Pharmacologica Sinica 2005, 26: 1352-1358. PMID: 16225758, DOI: 10.1111/j.1745-7254.2005.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory Agents, Non-SteroidalArtemisininsCell ProliferationCells, CulturedCytokinesDose-Response Relationship, DrugHemolysisHypersensitivity, DelayedImmunosuppressive AgentsInhibitory Concentration 50Interferon-gammaInterleukin-12Lymphocyte Culture Test, MixedMaleMiceMice, Inbred BALB CMice, Inbred C57BLSuccinatesConceptsDelayed-type hypersensitivityMixed lymphocyte reactionProliferation of splenocytesSheep red blood cellsImmunosuppressive agentsCytokine productionT-cell-mediated delayed-type hypersensitivityImmunosuppressive activityVivo immune activityProinflammatory cytokine productionIL-2 secretionNovel artemisinin derivativesEnzyme-linked immunosorbentDose-dependent mannerStrong immunosuppressive activityPotential immunosuppressive agentsRed blood cellsLymphocyte reactionImmunosuppressive effectsQuantitative hemolysisImmune activityMouse modelArtemisinin derivativesConA stimulationBlood cells(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo
Zhou R, Zhang F, He P, Zhou W, Wu Q, Xu J, Zhou Y, Tang W, Li X, Yang Y, Li Y, Zuo J. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo. International Immunopharmacology 2005, 5: 1895-1903. PMID: 16275624, DOI: 10.1016/j.intimp.2005.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell ProliferationCell SurvivalCells, CulturedCytokinesDinitrofluorobenzeneDisease Models, AnimalDiterpenesDrugs, Chinese HerbalFemaleHypersensitivity, DelayedImmunosuppressive AgentsLymphocyte ActivationLymphocyte Culture Test, MixedMaleMiceMice, Inbred BALB CSheepSpleenT-LymphocytesConceptsLLDT-8Immunosuppressive activityBLAB/c miceType hypersensitivity reactionSheep red blood cellsTh1-type cytokinesHumoral immune responseProliferation of splenocytesImmune-related diseasesHigh immunosuppressive activityPotential therapeutic agentNovel triptolide analogRed blood cellsLymphocyte reactionHypersensitivity reactionsImmunosuppressive effectsInflammatory cytokinesLow acute toxicityC miceImmune responseType cytokinesTriptolide analoguesAntibody productionTherapeutic agentsBlood cellsSynthesis and Immunosuppressive Activity of New Artemisinin Derivatives. 1. [12(β or α)-Dihydroartemisininoxy]phen(ox)yl Aliphatic Acids and Esters
Yang Z, Zhou W, Sui Y, Wang J, Wu J, Zhou Y, Zhang Y, He P, Han J, Tang W, Li Y, Zuo J. Synthesis and Immunosuppressive Activity of New Artemisinin Derivatives. 1. [12(β or α)-Dihydroartemisininoxy]phen(ox)yl Aliphatic Acids and Esters. Journal Of Medicinal Chemistry 2005, 48: 4608-4617. PMID: 15999998, DOI: 10.1021/jm048979c.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationArtemisininsB-LymphocytesCell ProliferationConcanavalin ADinitrofluorobenzeneErythrocytesEstersFatty AcidsFemaleHypersensitivity, DelayedImmunosuppressive AgentsIn Vitro TechniquesLipopolysaccharidesMaleMiceMice, Inbred BALB CMitogensSesquiterpenesSheepStructure-Activity RelationshipT-LymphocytesConceptsB cell proliferationSheep red blood cellsT cell proliferationCell proliferationImmunosuppressive activityDelayed-type hypersensitivity reactionCytotoxicity of lymphocytesNew artemisinin derivativesPotential immunosuppressive agentsRed blood cellsImmunosuppressive agentsHypersensitivity reactionsT cellsInhibition activityArtemisinin derivativesAntibody productionCyclosporin ADihydroartemisinin derivativesBlood cellsInhibitory effectHigh efficacyLipopolysaccharideConcanavalin AProliferationHighest inhibition activity
2002
Low dose of resveratrol enhanced immune response of mice.
Feng Y, Zhou W, Wu Q, Li X, Zhao W, Zou J. Low dose of resveratrol enhanced immune response of mice. Acta Pharmacologica Sinica 2002, 23: 893-7. PMID: 12370094.Peer-Reviewed Original ResearchConceptsCytokine productionLymphocyte subtypesImmune responseLow doseMHC-II molecule expressionCell-mediated immune responsesLow-dose resveratrolType hypersensitivity responseImmune modulating effectsTh1 cytokine productionIL-10 productionIFN-gamma productionStaphylococcus aureus CowanResponse of miceIL-2 productionProliferation of lymphocytesEar swellingIL-12Hypersensitivity responseLymphocyte proliferationMacrophage percentageMolecule expressionT lymphocytesResveratrol treatmentEthanol consumption