2022
Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs
Mineur YS, Mose TN, Vanopdenbosch L, Etherington IM, Ogbejesi C, Islam A, Pineda CM, Crouse RB, Zhou W, Thompson DC, Bentham MP, Picciotto MR. Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs. Molecular Psychiatry 2022, 27: 1829-1838. PMID: 34997190, PMCID: PMC9106825, DOI: 10.1038/s41380-021-01404-7.Peer-Reviewed Original ResearchConceptsStress-related behaviorsCholinergic inputMedial septum/diagonal bandBehavioral effectsBrain ACh levelsChAT-positive neuronsSelective chemogenetic activationMuscarinic ACh receptorsDepression-like symptomsSignificant behavioral effectsHippocampal acetylcholineMaladaptive behavioral responsesAntidepressant effectsCholinergic neuronsACh releaseChemogenetic activationChemogenetic inhibitionCholinergic antagonistsLocal infusionAcetylcholine levelsACh levelsDiagonal bandACh receptorsHippocampal neuronsPharmacological approaches
2014
Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex
Moore A, Zhou W, Sirois C, Belinsky G, Zecevic N, Antic S. Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e3919-e3928. PMID: 25197082, PMCID: PMC4169969, DOI: 10.1073/pnas.1405253111.Peer-Reviewed Original ResearchConceptsHuman fetal cortexAction potential firingFetal cortexSP neuronsSpontaneous activitySpontaneous depolarizationsYoung postmitotic neuronsGlycinergic synaptic transmissionConnexin-based gap junctionsElectrical activityAcute cortical slicesSpontaneous electrical activityWhole-cell recordingsConnexin hemichannelsGap junctionsHuman subplate neuronsPresence of connexinsSubplate neuronsSecond trimesterCortical slicesSynaptic contactsSynaptic transmissionImmunohistochemical analysisSP zonePostmitotic neurons
2011
Spontaneous Electrical Activity in the Human Fetal Cortex In Vitro
Moore A, Zhou W, Jakovcevski I, Zecevic N, Antic S. Spontaneous Electrical Activity in the Human Fetal Cortex In Vitro. Journal Of Neuroscience 2011, 31: 2391-2398. PMID: 21325506, PMCID: PMC3564513, DOI: 10.1523/jneurosci.3886-10.2011.Peer-Reviewed Original ResearchConceptsAction potential firingSpontaneous electrical activitySP neuronsPlateau depolarizationsHuman fetal neuronsElectrical activityHuman fetal cortexFunctional synaptic contactsHuman cerebral cortexSpontaneous network activitySlow-wave sleepHuman postmortem tissueSlow oscillatory patternsGABA ionotropic receptorsHuman subplate neuronsFetal neuronsSubplate neuronsCerebral cortexGestational weeksSynaptic contactsFetal cortexPostsynaptic potentialsCortical neuronsAdult neocortexSynaptic inputs
2010
The decade of the dendritic NMDA spike
Antic S, Zhou W, Moore A, Short S, Ikonomu K. The decade of the dendritic NMDA spike. Journal Of Neuroscience Research 2010, 88: 2991-3001. PMID: 20544831, PMCID: PMC5643072, DOI: 10.1002/jnr.22444.Peer-Reviewed Original ResearchConceptsDendritic NMDA spikesNMDA spikesPyramidal cellsPlateau potentialsActive synaptic inputsApical tuft dendritesGlutamatergic synaptic contactsThick apical dendritesLong-term synaptic modificationsNeuronal cell bodiesCortical pyramidal cellsSlow-wave sleepCortical UP statesDendritic regenerative potentialsCortical information processingBasal dendritesPyramidal neuronsApical dendritesSynaptic contactsApical trunkTuft dendritesSynaptic inputsProximal segmentThin dendritesAwake animals