2023
Network analysis of ecological momentary assessment identifies frustration as a central node in irritability
Tseng W, Naim R, Chue A, Shaughnessy S, Meigs J, Pine D, Leibenluft E, Kircanski K, Brotman M. Network analysis of ecological momentary assessment identifies frustration as a central node in irritability. Journal Of Child Psychology And Psychiatry 2023, 64: 1212-1221. PMID: 36977629, PMCID: PMC10615387, DOI: 10.1111/jcpp.13794.Peer-Reviewed Original Research
2021
Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study
Lee KS, Xiao J, Liew Z, Gau SS, Tseng WL. Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study. Journal Of Affective Disorders 2021, 299: 273-280. PMID: 34906640, PMCID: PMC8767526, DOI: 10.1016/j.jad.2021.12.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentFemaleHumansIrritable MoodMood DisordersProspective StudiesReproducibility of ResultsRetrospective StudiesTaiwanConceptsNational epidemiological studyBirth characteristicsEpidemiological studiesChildhood irritabilityEarly life exposureAdverse mental healthBirth correlatesPerinatal perspectiveVaginal bleedingMaternal smokingAffective Reactivity IndexPerinatal risksBirth factorsLife exposureProspective assessmentIrritabilityTemper outburstsRecall biasLife outcomesPerinatalMental healthEarly etiologyChild irritabilityRetrospective assessmentEnvironmental exposuresFunctional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2020
Psychiatric comorbidity and social adjustment difficulties in children with disruptive mood dysregulation disorder: A national epidemiological study
Lin YJ, Tseng WL, Gau SS. Psychiatric comorbidity and social adjustment difficulties in children with disruptive mood dysregulation disorder: A national epidemiological study. Journal Of Affective Disorders 2020, 281: 485-492. PMID: 33383391, PMCID: PMC8142276, DOI: 10.1016/j.jad.2020.12.039.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderOppositional defiant disorderSocial adjustment difficultiesAdjustment difficultiesPsychiatric comorbiditySocial Adjustment InventoryKiddie epidemiologic versionParent-child interactionsChildhood mental disordersAdjustment InventoryDefiant disorderEpidemiologic VersionParental educational levelAcademic performanceMore difficultyDSM-5More problemsHigh psychiatric comorbiditySchool functionTaiwanese childrenMental disordersNational epidemiological studyChildrenAffective disordersSevere impairmentEditorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability
Tseng WL. Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 1327-1329. PMID: 32966839, PMCID: PMC8143431, DOI: 10.1016/j.jaac.2020.09.008.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderAttention-deficit/hyperactivity disorderOppositional defiant disorderLong-term impairmentDSM-5 categoriesPediatric disordersHigh suicidalityAnxiety disordersHyperactivity disorderDisordersIrritabilityDefiant disorderHallmark featurePediatric irritabilityTransdiagnostic symptomsNeural mechanismsTransdiagnostic approachAutism spectrum disorderChild psychiatrySpectrum disorder
2019
Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes
Tsai FJ, Tseng WL, Yang LK, Gau SS. Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes. PLOS ONE 2019, 14: e0211873. PMID: 30730956, PMCID: PMC6366698, DOI: 10.1371/journal.pone.0211873.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDrug-naïve adultsChildhood attention-deficit/hyperactivity disorderPsychiatric comorbidityMedication treatmentHigh riskTreatment durationHyperactivity disorderSemi-structured psychiatric interviewCurrent medication treatmentHealthy adult controlsEffects of medicationLonger treatment durationShorter treatment durationAttention deficit hyperactivity disorderADHD inattentive subtypeMore comorbiditiesMedical recordsHealthy controlsMood disordersSleep disordersComorbiditiesPsychiatric interviewLower riskADHD subtypes
2018
A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces
2017
Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces
2015
Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation
Tseng WL, Thomas LA, Harkins E, Pine DS, Leibenluft E, Brotman MA. Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation. Social Cognitive And Affective Neuroscience 2015, 11: 78-88. PMID: 26137973, PMCID: PMC4692312, DOI: 10.1093/scan/nsv087.Peer-Reviewed Original ResearchConceptsSevere mood dysregulationFace emotion processingFunctional magnetic resonance imagingEmotion processingParahippocampal gyrusNeural correlatesMood dysregulationVentromedial prefrontal cortex activationAffective priming paradigmPrefrontal cortex activationSuperior temporal gyrusAngry facesFace processingHappy facesSMD patientsPositive emotionsPriming paradigmVmPFC dysfunctionNegative emotionsTemporal gyrusCortex activationEmotionsFMRI dataDecreased activationIndependent samples
2013
A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders
Tseng WL, Leibenluft E, Brotman MA. A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders. 2013, 16: 297-317. PMID: 24281907, PMCID: PMC4482127, DOI: 10.1007/7854_2013_252.Peer-Reviewed Original ResearchConceptsPediatric moodAnxiety disordersFunctional magnetic resonance imaging (fMRI) researchSystems neuroscience approachMagnetic resonance imaging researchNeuroscience approachEmotional dysregulationNeural mechanismsBehavioral findingsCore featuresImaging researchMoodFuture researchPotential novel treatmentDisordersNovel treatmentsResearchBrainFindingsChapterPathophysiologyRelationshipDysregulationAbnormalities