2018
Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis
Fryer SL, Roach BJ, Ford JM, Donaldson KR, Calhoun VD, Pearlson GD, Kiehl KA, Srihari VH, McGlashan TH, Woods SW, Mathalon DH. Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis. Schizophrenia Bulletin 2018, 45: 158-168. PMID: 29385625, PMCID: PMC6293268, DOI: 10.1093/schbul/sbx198.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high riskESZ groupsBilateral dorsal anterior cingulateResponse inhibitionGo/NoGo task performanceEarly illness schizophreniaInhibitory control regionsVariable motor responseTask-based functional connectivityFunctional connectivity relationshipsDorsal anterior cingulateMedial prefrontal cortexDefault mode network regionsInferior frontal cortexRight inferior frontal regionsFunctional magnetic resonanceFrontal cortexHigh riskHealthy adolescentsSchizophrenia patientsAnterior cingulateControl groupInferior frontal regionsCHR group
2013
Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity
Perez VB, Woods SW, Roach BJ, Ford JM, McGlashan TH, Srihari VH, Mathalon DH. Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity. Biological Psychiatry 2013, 75: 459-469. PMID: 24050720, PMCID: PMC4028131, DOI: 10.1016/j.biopsych.2013.07.038.Peer-Reviewed Original ResearchConceptsCHR patientsHealthy control subjectsPsychosis onsetControl subjectsClinical high-risk patientsEarly illness schizophrenia patientsPsychosis riskClinical high-risk individualsHigh-risk patientsThird of patientsHigh-risk individualsCurrent clinical criteriaAuditory processing deficitsMismatch negativityNonclinical measuresAuditory devianceCox regressionClinical criteriaUnnecessary treatmentHigh riskCHR convertersPatientsPsychotic disordersSchizophrenia patientsPreventive interventions