The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: A double-blind, randomized, placebo-controlled trial
Tek C, Palmese LB, Krystal AD, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S. The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: A double-blind, randomized, placebo-controlled trial. Schizophrenia Research 2014, 160: 180-185. PMID: 25454802, PMCID: PMC5589464, DOI: 10.1016/j.schres.2014.10.002.Peer-Reviewed Original ResearchMeSH KeywordsAzabicyclo CompoundsCognitionDouble-Blind MethodEszopicloneFemaleHumansHypnotics and SedativesMaleMedical RecordsMiddle AgedPatient DropoutsPiperazinesPsychotic DisordersQuality of LifeSchizophreniaSchizophrenic PsychologySingle-Blind MethodSleepSleep Initiation and Maintenance DisordersTreatment OutcomeConceptsInsomnia Severity IndexSingle-blind placebo phasePlacebo phaseOutcome measuresPsychiatric symptomsPlacebo-controlled trialDouble-blind placeboSecondary outcome measuresPrimary outcome measureEffects of eszopicloneBetween-group differencesTreatment of insomniaQuality of lifeDiscontinuation ratesMATRICS Consensus Cognitive BatteryStable outpatientsConsensus Cognitive BatterySchizoaffective disorderCognitive impairmentSleep diaryPatientsInsomniaScore changeEszopiclonePlacebo