2014
High Rates of Obstructive Sleep Apnea Symptoms Among Patients With Schizophrenia
Annamalai A, Palmese LB, Chwastiak LA, Srihari VH, Tek C. High Rates of Obstructive Sleep Apnea Symptoms Among Patients With Schizophrenia. Journal Of The Academy Of Consultation-Liaison Psychiatry 2014, 56: 59-66. PMID: 25023923, PMCID: PMC5583522, DOI: 10.1016/j.psym.2014.02.009.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSevere mental illnessSTOP questionnaireSleep apneaHigh riskLarge urban community mental health centerMental illnessDiagnosis of OSAUrban community mental health centerCommunity mental health centerBody mass indexHigh-risk groupCross-sectional studyHigh clinical utilityMental health centersSample of outpatientsHigh rateOSA symptomsCardiovascular morbiditySurgical populationMass indexRisk factorsHealth centersSTOP scoreClinical utility
2013
Investigating the safety and efficacy of naltrexone for anti-psychotic induced weight gain in severe mental illness: study protocol of a double-blind, randomized, placebo-controlled trial
Tek C, Guloksuz S, Srihari VH, Reutenauer EL. Investigating the safety and efficacy of naltrexone for anti-psychotic induced weight gain in severe mental illness: study protocol of a double-blind, randomized, placebo-controlled trial. BMC Psychiatry 2013, 13: 176. PMID: 23805859, PMCID: PMC3702521, DOI: 10.1186/1471-244x-13-176.Peer-Reviewed Original ResearchConceptsSevere mental illnessEfficacy of naltrexoneWeight gainOutcome measurementsHealth problemsMental illnessGreater New Haven areaTumor necrosis factor alphaWeight lossCurrent available medicationsPlacebo-controlled trialHigh-sensitivity CRPOpioid receptor antagonistSecondary outcome measuresSerum lipid profilePrimary outcome measurementBody mass indexD2 receptor blockadeEffects of naltrexoneNovel pharmacological optionsNecrosis factor alphaDoses of naltrexoneMajor health problemRates of obesitySignificant weight loss
2011
Insomnia is frequent in schizophrenia and associated with night eating and obesity
Palmese LB, DeGeorge PC, Ratliff JC, Srihari VH, Wexler BE, Krystal AD, Tek C. Insomnia is frequent in schizophrenia and associated with night eating and obesity. Schizophrenia Research 2011, 133: 238-243. PMID: 21856129, PMCID: PMC5581545, DOI: 10.1016/j.schres.2011.07.030.Peer-Reviewed Original ResearchConceptsBody mass indexQuality of lifeSleep difficultiesMass indexClinical insomniaSevere insomniaNight eatingPoor sleepPsychiatric symptomsTypes of antipsychoticsPrevalence of insomniaRelationship of sleepProminent clinical concernBrief cognitive assessmentIndependent predictorsPoint prevalenceClinical variablesClinical careSleep patternsSchizoaffective disorderClinical concernInsomniaLow qualityWeight gainSchizophreniaCardiovascular risk in a first-episode psychosis sample: A ‘critical period’ for prevention?
Phutane VH, Tek C, Chwastiak L, Ratliff JC, Ozyuksel B, Woods SW, Srihari VH. Cardiovascular risk in a first-episode psychosis sample: A ‘critical period’ for prevention? Schizophrenia Research 2011, 127: 257-261. PMID: 21242060, PMCID: PMC3051021, DOI: 10.1016/j.schres.2010.12.008.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseFirst-episode psychosis patientsFirst-episode psychosis sampleEpisode psychosis patientsHeart diseaseCardiovascular riskPsychosis patientsPlasma glucoseRisk factorsFirst-episode psychosis clinicNational Cholesterol Education ProgramPsychosis sampleCardiovascular risk factorsHigh cardiovascular riskStatus of diabetesCholesterol Education ProgramBody mass indexCommon medical illnessesU.S. National HealthNutrition Examination SurveyRace-matched controlsIndividual risk factorsEarly intervention clinicCross-sectional analysisCardiovascular morbidity