2024
A multimodal Neuroimaging-Based risk score for mild cognitive impairment
Zendehrouh E, Sendi M, Abrol A, Batta I, Hassanzadeh R, Calhoun V. A multimodal Neuroimaging-Based risk score for mild cognitive impairment. NeuroImage Clinical 2024, 45: 103719. PMID: 39637673, PMCID: PMC11664180, DOI: 10.1016/j.nicl.2024.103719.Peer-Reviewed Original ResearchMild cognitive impairment riskMild cognitive impairmentMild cognitive impairment groupRisk of mild cognitive impairmentRisk scoreUK Biobank participantsFunctional network connectivityCognitive impairmentPrecursor to ADSignificant cognitive declineBiobank participantsUK BiobankMild cognitive impairment individualsGenetic risk factorsAlzheimer's diseaseFunctional MRIHigh-risk groupStructural MRIAD riskRisk factorsCognitive declineFeatures of CNGray matterDifferentiate CNParticipantsCorrelates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health
Burzynska A, Anderson C, Arciniegas D, Calhoun V, Choi I, Mendez Colmenares A, Kramer A, Li K, Lee J, Lee P, Thomas M. Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health. Cerebral Circulation - Cognition And Behavior 2024, 6: 100203. PMID: 38292016, PMCID: PMC10827486, DOI: 10.1016/j.cccb.2024.100203.Peer-Reviewed Original ResearchNeurologically healthy adultsHealthy adultsLow metabolic riskAdult spanNeural targetsSex differencesIntracranial volumeModifiable health risk factorsMetabolic riskMyelin contentHealth risk factorsAlzheimer's diseaseWhite matterNeurite orientation dispersionPeripheral metabolismMRI approachModifiable factorsAdiposity scoreAdultsMetabolic healthRisk factorsMetabolic syndromeVulnerabilityNeurologyWM
2023
Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults
Burzynska A, Anderson C, Arciniegas D, Calhoun V, Choi I, Colmenares A, Hiner G, Kramer A, Li K, Lee J, Lee P, Oh S, Umland S, Thomas M. Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults. Cerebral Circulation - Cognition And Behavior 2023, 5: 100180. PMID: 38162292, PMCID: PMC10757180, DOI: 10.1016/j.cccb.2023.100180.Peer-Reviewed Original ResearchMetS risk scoreRisk scoreRisk factorsMetabolic syndromeCognitively healthy adultsHealthy adultsTreatment of cognitive declineNeurologically healthy adultsCluster of conditionsPathophysiology of dementiaElevated blood pressureExcess adiposityChronic diseasesContext of MetSRandomized clinical trialsMyelin water fractionWhite matterDementiaCognitive dysfunctionCognitive declineMaintenance of myelin integrityLate-myelinatingMetSAdiposity reductionAssociation fibers