2024
Cross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia
Zhao C, Jiang R, Bustillo J, Kochunov P, Turner J, Liang C, Fu Z, Zhang D, Qi S, Calhoun V. Cross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia. Human Brain Mapping 2024, 45: e26694. PMID: 38727014, PMCID: PMC11083889, DOI: 10.1002/hbm.26694.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNegative symptomsFunctional connectivityCognitive impairmentPrediction of negative symptomsResting-state functional connectivityAssociated with reduced cognitive functionDebilitating mental illnessHealthy controlsPredicting functional connectivityEarly adulthood onsetPositive symptomsNeural underpinningsSchizophreniaCognitive functionSensorimotor networkPredicting symptomsMental illnessConnectivity patternsClinical interventionsMagnetic resonance imagingAdulthood onsetSymptomsImpairmentResonance imagingMRI morphometry of the anterior and posterior cerebellar vermis and its relationship to sensorimotor and cognitive functions in children
Hodgdon E, Anderson R, Al Azzawi H, Wilson T, Calhoun V, Wang Y, Solis I, Greve D, Stephen J, Ciesielski K. MRI morphometry of the anterior and posterior cerebellar vermis and its relationship to sensorimotor and cognitive functions in children. Developmental Cognitive Neuroscience 2024, 67: 101385. PMID: 38713999, PMCID: PMC11096723, DOI: 10.1016/j.dcn.2024.101385.Peer-Reviewed Original ResearchConceptsLobules I-VCognitive functionCerebellar vermis volumePosterior brain structuresCerebellar vermisVI-VIIAnterior cerebellar vermisLobules VI-VIIWASI-IIEmotional processingVermis volumeNeuropsychological scoresPosterior cerebellar vermisBrain structuresDevelopmental trajectoriesMRI morphometryCerebellar anatomyPosterior vermisSensorimotorDevelopmental studiesHuman cerebellumHealthy adultsAdult volumeVermisHigh-resolution MRIA whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry
Jensen K, Calhoun V, Fu Z, Yang K, Faria A, Ishizuka K, Sawa A, Andrés-Camazón P, Coffman B, Seebold D, Turner J, Salisbury D, Iraji A. A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry. NeuroImage Clinical 2024, 41: 103584. PMID: 38422833, PMCID: PMC10944191, DOI: 10.1016/j.nicl.2024.103584.Peer-Reviewed Original ResearchConceptsFunctional network connectivityFirst-episodeEarly psychosisAberrant functional network connectivityResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingCorrelates of psychosisResting-state fMRI analysisWhole-brain approachPsychiatric disordersPsychiatric illnessSubcortical regionsCerebellar regionsFMRI analysisPsychosisControl participantsCognitive functionRs-fMRICerebellar connectivityMulti-site datasetFunctional circuitryMagnetic resonance imagingCircuitryResonance imagingProminent patternRevealing complex functional topology brain network correspondences between humans and marmosets
Li Q, Calhoun V, Iraji A. Revealing complex functional topology brain network correspondences between humans and marmosets. Neuroscience Letters 2024, 822: 137624. PMID: 38218321, DOI: 10.1016/j.neulet.2024.137624.Peer-Reviewed Original ResearchConceptsWhole-brain functional connectivityFunctional brain connectivityDorsal attention networkFunctional connectivity patternsBrain connectivityMarmoset monkey brainBrain networksTopological characteristicsMode networkFunctional connectivityCognitive functionVisual networkNon-human primatesMonkey brainAttention networkConnectivity patternsNeural connectionsBrainFunctional correspondenceConnectome
2022
Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer’s disease
Hajjar I, Okafor M, Wan L, Yang Z, Nye J, Bohsali A, Shaw L, Levey A, Lah J, Calhoun V, Moore R, Goldstein F. Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer’s disease. Brain Communications 2022, 4: fcac270. PMID: 36440097, PMCID: PMC9683395, DOI: 10.1093/braincomms/fcac270.Peer-Reviewed Original ResearchProdromal Alzheimer's diseaseMild cognitive impairmentCognitive effectsCognitive functionCognitive impairmentNon-hypertensive individualsAlzheimer's diseasePositive cognitive effectsAssociated with improved executive functionComposite cognitive scoreGlobal cognitive functionFunctional network connectivityImproving global cognitive functionBrain amyloid accumulationExecutive functionExploratory outcomesCognitive measuresSubcortical networksHippocampal volumeNon-hypertensive adultsFalse discovery rate correctionParahippocampal regionIntention-to-treat approachPlacebo-controlled trialNon-hypertensive participants