Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
García-Marín L, Campos A, Diaz-Torres S, Rabinowitz J, Ceja Z, Mitchell B, Grasby K, Thorp J, Agartz I, Alhusaini S, Ames D, Amouyel P, Andreassen O, Arfanakis K, Arias-Vasquez A, Armstrong N, Athanasiu L, Bastin M, Beiser A, Bennett D, Bis J, Boks M, Boomsma D, Brodaty H, Brouwer R, Buitelaar J, Burkhardt R, Cahn W, Calhoun V, Carmichael O, Chakravarty M, Chen Q, Ching C, Cichon S, Crespo-Facorro B, Crivello F, Dale A, Smith G, de Geus E, De Jager P, de Zubicaray G, Debette S, DeCarli C, Depondt C, Desrivières S, Djurovic S, Ehrlich S, Erk S, Espeseth T, Fernández G, Filippi I, Fisher S, Fleischman D, Fletcher E, Fornage M, Forstner A, Francks C, Franke B, Ge T, Goldman A, Grabe H, Green R, Grimm O, Groenewold N, Gruber O, Gudnason V, Håberg A, Haukvik U, Heinz A, Hibar D, Hilal S, Himali J, Ho B, Hoehn D, Hoekstra P, Hofer E, Hoffmann W, Holmes A, Homuth G, Hosten N, Ikram M, Ipser J, Jack Jr C, Jahanshad N, Jönsson E, Kahn R, Kanai R, Klein M, Knol M, Launer L, Lawrie S, Hellard S, Lee P, Lemaître H, Li S, Liewald D, Lin H, Longstreth W, Lopez O, Luciano M, Maillard P, Marquand A, Martin N, Martinot J, Mather K, Mattay V, McMahon K, Mecocci P, Melle I, Meyer-Lindenberg A, Mirza-Schreiber N, Milaneschi Y, Mosley T, Mühleisen T, Müller-Myhsok B, Maniega S, Nauck M, Nho K, Niessen W, Nöthen M, Nyquist P, Oosterlaan J, Pandolfo M, Paus T, Pausova Z, Penninx B, Pike G, Psaty B, Pütz B, Reppermund S, Rietschel M, Risacher S, Romanczuk-Seiferth N, Romero-Garcia R, Roshchupkin G, Rotter J, Sachdev P, Sämann P, Saremi A, Sargurupremraj M, Saykin A, Schmaal L, Schmidt H, Schmidt R, Schofield P, Scholz M, Schumann G, Schwarz E, Shen L, Shin J, Sisodiya S, Smith A, Smoller J, Soininen H, Steen V, Stein D, Stein J, Thomopoulos S, Toga A, Tordesillas-Gutiérrez D, Trollor J, Valdes-Hernandez M, van ′t Ent D, van Bokhoven H, van der Meer D, van der Wee N, Vázquez-Bourgon J, Veltman D, Vernooij M, Villringer A, Vinke L, Völzke H, Walter H, Wardlaw J, Weinberger D, Weiner M, Wen W, Westlye L, Westman E, White T, Witte A, Wolf C, Yang J, Zwiers M, Ikram M, Seshadri S, Thompson P, Satizabal C, Medland S, Rentería M. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nature Genetics 2024, 56: 2333-2344. PMID: 39433889, DOI: 10.1038/s41588-024-01951-z.Peer-Reviewed Original ResearchSubcortical brain volumesBrain volumePolygenic scoresEffects of brain volumeAttention-deficit/hyperactivity disorderIndividuals of diverse ancestryComorbid neuropsychiatric disordersSubcortical brain structuresGenome-wide association study meta-analysesBrain substratesParticipants of European ancestryAttention-deficit/hyperactivityGene expression patternsNeuropsychiatric disordersDifferentiation time pointsBrain structuresGenomic analysisDiverse ancestryBrain developmentStudy meta-analysesGenetic variantsNeural cell typesPhenotypic varianceRisk genesAging-related processesVerbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis
Kennedy E, Liebel S, Lindsey H, Vadlamani S, Lei P, Adamson M, Alda M, Alonso-Lana S, Anderson T, Arango C, Asarnow R, Avram M, Ayesa-Arriola R, Babikian T, Banaj N, Bird L, Borgwardt S, Brodtmann A, Brosch K, Caeyenberghs K, Calhoun V, Chiaravalloti N, Cifu D, Crespo-Facorro B, Dalrymple-Alford J, Dams-O’Connor K, Dannlowski U, Darby D, Davenport N, DeLuca J, Diaz-Caneja C, Disner S, Dobryakova E, Ehrlich S, Esopenko C, Ferrarelli F, Frank L, Franz C, Fuentes-Claramonte P, Genova H, Giza C, Goltermann J, Grotegerd D, Gruber M, Gutierrez-Zotes A, Ha M, Haavik J, Hinkin C, Hoskinson K, Hubl D, Irimia A, Jansen A, Kaess M, Kang X, Kenney K, Keřková B, Khlif M, Kim M, Kindler J, Kircher T, Knížková K, Kolskår K, Krch D, Kremen W, Kuhn T, Kumari V, Kwon J, Langella R, Laskowitz S, Lee J, Lengenfelder J, Liou-Johnson V, Lippa S, Løvstad M, Lundervold A, Marotta C, Marquardt C, Mattos P, Mayeli A, McDonald C, Meinert S, Melzer T, Merchán-Naranjo J, Michel C, Morey R, Mwangi B, Myall D, Nenadić I, Newsome M, Nunes A, O’Brien T, Oertel V, Ollinger J, Olsen A, de la Foz V, Ozmen M, Pardoe H, Parent M, Piras F, Piras F, Pomarol-Clotet E, Repple J, Richard G, Rodriguez J, Rodriguez M, Rootes-Murdy K, Rowland J, Ryan N, Salvador R, Sanders A, Schmidt A, Soares J, Spalleta G, Španiel F, Sponheim S, Stasenko A, Stein F, Straube B, Thames A, Thomas-Odenthal F, Thomopoulos S, Tone E, Torres I, Troyanskaya M, Turner J, Ulrichsen K, Umpierrez G, Vecchio D, Vilella E, Vivash L, Walker W, Werden E, Westlye L, Wild K, Wroblewski A, Wu M, Wylie G, Yatham L, Zunta-Soares G, Thompson P, Pugh M, Tate D, Hillary F, Wilde E, Dennis E. Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis. Brain Sciences 2024, 14: 669. PMID: 39061410, PMCID: PMC11274572, DOI: 10.3390/brainsci14070669.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderVerbal learningNeuropsychiatric conditionsTraumatic brain injuryYears of educationMild cognitive impairmentComorbid disordersAttention-deficit/hyperactivityBipolar disorderMemory deficitsMemory performanceMemory recallClinical groupsMega-analysisCognitive impairmentEffects of dementiaAssociated with dementiaMemoryBrain injurySchizophreniaMemory impactDisordersDepressionParkinson's diseaseUnique participants