Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study
Rapoport JL, Giedd JN, Blumenthal J, Hamburger S, Jeffries N, Fernandez T, Nicolson R, Bedwell J, Lenane M, Zijdenbos A, Paus T, Evans A. Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study. JAMA Psychiatry 1999, 56: 649-654. PMID: 10401513, DOI: 10.1001/archpsyc.56.7.649.Peer-Reviewed Original ResearchConceptsChildhood-onset schizophreniaCortical gray matter volumeWhite matter volumeDisease-specific patternsGray matter volumeMatter volumeHealthy controlsCortical changesBrain tissueGray matterSchizophrenia groupLongitudinal magnetic resonance imaging studyBrain developmentBrain ventricular enlargementProgressive cortical changesMagnetic resonance imaging studyBrain magnetic resonanceEarly-onset schizophreniaTemporal gray matterAbnormal brain developmentResonance imaging studyVentricular enlargementMean ageOnset schizophreniaPatient's illness