Childhood-onset schizophrenia: progressive brain changes during adolescence
Giedd J, Jeffries N, Blumenthal J, Castellanos FX, Vaituzis A, Fernandez T, Hamburger S, Liu H, Nelson J, Bedwell J, Tran L, Lenane M, Nicolson R, Rapoport J. Childhood-onset schizophrenia: progressive brain changes during adolescence. Biological Psychiatry 1999, 46: 892-898. PMID: 10509172, DOI: 10.1016/s0006-3223(99)00072-4.Peer-Reviewed Original ResearchConceptsBrain anomaliesVentricular volumeTotal cerebrumLateral ventricleCOS groupDuration of illnessProgressive brain changesBrain magnetic resonanceStructural brain anomaliesBrain MRI studiesGender-matched controlsMean age 14Age-related changesAdult patientsAdult schizophreniaBrain changesMRI studiesControl groupLarger sample sizeBrain tissueBrain developmentHippocampusProgressionDiagnostic group differencesEarly adulthood