2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Chuang H, Prescott E, Kong H, Shields S, Jordt S, Basbaum A, Chao M, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 2001, 411: 957-962. PMID: 11418861, DOI: 10.1038/35082088.Peer-Reviewed Original ResearchConceptsPlasma membrane phosphatidylinositolNerve growth factorTyrosine kinase receptorsActivation of PLCGrowth factorTRP channel familyMembrane phosphatidylinositolChannel familyKinase receptorsBiochemical mechanismsMolecular levelBiochemical studiesIon channelsCellular levelChannel activityHeat-activated ion channelExpression of VR1Sensory nerve endingsChemical stimuliSense of painSensory neuronsEndogenous factorsPrimary afferentsNerve endingsCapsaicin receptor
1999
Chloride dependence of hyperpolarization‐activated chloride channel gates
Pusch M, Jordt S, Stein V, Jentsch T. Chloride dependence of hyperpolarization‐activated chloride channel gates. The Journal Of Physiology 1999, 515: 341-353. PMID: 10050002, PMCID: PMC2269146, DOI: 10.1111/j.1469-7793.1999.341ac.x.Peer-Reviewed Original Research
1998
Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neurons
Clark S, Jordt S, Jentsch T, Mathie A. Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neurons. The Journal Of Physiology 1998, 506: 665-678. PMID: 9503329, PMCID: PMC2230754, DOI: 10.1111/j.1469-7793.1998.665bv.x.Peer-Reviewed Original ResearchConceptsSCG neuronsRat superior cervical ganglion neuronsChloride currentsSuperior cervical ganglion neuronsConventional whole-cell recordingRat SCG neuronsClC-2Rat cerebellar granule cellsRat sympathetic neuronsPerforated-patch recordingsWhole-cell recordingsHyperpolarization-activated chloride currentCerebellar granule cellsTranscriptase-polymerase chain reaction experimentsPresence of mRNAGanglion neuronsSympathetic neuronsGABAA receptorsMM cesiumGranule cellsEffective blockerExternal potassium concentrationCl- currentInternal chloride concentrationHyperpolarization-activated Cl- current