2020
Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets
Achanta S, Jordt S. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Annals Of The New York Academy Of Sciences 2020, 1480: 73-103. PMID: 32892378, PMCID: PMC7933981, DOI: 10.1111/nyas.14472.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium SignalingChemical Warfare AgentsHumansLungLung InjuryTRPA1 Cation ChannelTRPV Cation ChannelsConceptsChemical injuryTRP channelsNeurogenic inflammatory pathwaysChemical threat agentsMediator of injuryTransient receptor potential channelsTransient receptor potential (TRP) ion channelsIntracellular calcium levelsToxic inhalation hazardPotential ion channelsCough reflexPulmonary injuryPulmonary edemaProinflammatory cellsInflammatory pathwaysPathophysiologic eventsOccupational exposureMucus clearanceCalcium levelsInjuryNonneuronal pathwaysRespiratory systemBroader indicationsPotential channelsInhalation hazard
2018
Formation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids
Erythropel HC, Jabba SV, DeWinter TM, Mendizabal M, Anastas PT, Jordt SE, Zimmerman JB. Formation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. Nicotine & Tobacco Research 2018, 21: 1248-1258. PMID: 30335174, PMCID: PMC6698951, DOI: 10.1093/ntr/nty192.Peer-Reviewed Original ResearchConceptsFlavor aldehydesSolvent componentsNuclear magnetic resonance spectroscopyNovel chemical speciesReaction productsPhysiological aqueous solutionE-cigarette liquidsReactive chemical systemsToxicological propertiesCommercial e-liquidsMagnetic resonance spectroscopyE-liquidsAqueous mediaPropylene glycolAqueous solutionPotential toxicological effectsNew compoundsUltraviolet spectroscopyChemical speciesChemical reactionsGas chromatographyChemical systemsResonance spectroscopyToxicological effectsAldehydes
2013
TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis
Liu B, Escalera J, Balakrishna S, Fan L, Caceres A, Robinson E, Sui A, McKay M, McAlexander M, Herrick C, Jordt S. TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. The FASEB Journal 2013, 27: 3549-3563. PMID: 23722916, PMCID: PMC3752543, DOI: 10.1096/fj.13-229948.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisSubstance PScratching behaviorContact dermatitisSensory neuronsSP receptor antagonistTRPA1-deficient miceCommon skin diseaseChronic inflammatory responseTransient receptor potential (TRP) ion channelsNerve growth factorPotential ion channelsEndogenous pruritogensPruritic responsesPersistent pruritusCutaneous inflammationLeukocyte infiltrationInflammatory cytokinesSkin edemaReceptor antagonistAllergic responsesContact allergensInflammatory responseKeratinocyte hyperplasiaSP signaling
2011
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Willis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Irritation responseMenthol effectsCold-sensitive sensory neuronsSensory TRP channelsSmoking-related morbiditySensory irritation responseEffect of mentholTransient receptor potential melastatin 8 (TRPM8) ion channelActivation of TRPM8TRPM8 agonistTRPM8 antagonistsCapsaicin receptorRespiratory tractSensory neuronsAnkyrin 1Pharmacological actionsNicotine addictionSmoking behaviorRespiratory irritationTRP channelsAgonistsSmoke constituentsAvailable cigarettesCigarettes
2010
Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene
Lanosa M, Willis D, Jordt S, Morris J. Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene. Toxicological Sciences 2010, 115: 589-595. PMID: 20176620, PMCID: PMC2948824, DOI: 10.1093/toxsci/kfq057.Peer-Reviewed Original ResearchConceptsSensory irritation responseIrritation responseTransient receptor potential ankyrin 1 receptorMetabolic activationFemale C57BL/6J miceCytochrome P450 activationTRPA1 receptorsC57BL/6J miceCYP450 metabolitesPlethysmographic measurementsPpm styreneSensory irritationInhibitor metyraponeP450 activationPpm naphthaleneReceptorsMiceActivationCurrent studyCritical roleResponseMetyraponeIrritationRole
2009
A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.Peer-Reviewed Original ResearchConceptsAsthmatic airway inflammationAirway inflammationAirway hyperreactivityAllergen challengeHC-030031Airway allergen challengeEndogenous TRPA1 agonistsMurine ovalbumin modelImpaired inflammatory responseTreatment of asthmaRole of TRPA1Wild-type miceAirway epithelial functionAllergic inflammatory conditionsPromising pharmacological targetNeuronal ion channelsLipid peroxidation productsIon channelsAllergic asthmaAirway exposureEosinophil infiltrationLeukocyte infiltrationContractile stimuliInflammatory disordersOvalbumin model
2008
Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
Bessac BF, Jordt SE. Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control. Physiology 2008, 23: 360-370. PMID: 19074743, PMCID: PMC2735846, DOI: 10.1152/physiol.00026.2008.Peer-Reviewed Original ResearchConceptsReactive airways dysfunction syndromeAirway reflex responsesAirways dysfunction syndromeAirway inflammationChronic coughDysfunction syndromeTRP ion channelsReflex responsesReflex controlCapsaicin receptorChemical hypersensitivityTRPA1Reactive oxygen speciesInflammationTRPV1Noxious constituentsIon channelsOxygen speciesNew studiesCOPDCoughAsthmaSyndromeHypersensitivityIrritation
2007
Trp Channels In Disease
JORDT SE, EHRLICH BE. Trp Channels In Disease. Subcellular Biochemistry 2007, 45: 253-271. PMID: 18193640, DOI: 10.1007/978-1-4020-6191-2_9.Peer-Reviewed Original ResearchConceptsTRP channelsTransient receptor potential channelsPainful stimuliTRPA (ankyrin) groupsRole of TrpIntracellular Ca2Intracellular storesTRP channel physiologyDiseaseNormal physiologyChannel physiologySpecific diseasesPathophysiologyPotential channelsDifferent TRPsExtracellular stimuliMain subfamiliesDistinct functionsChemical signalsStimuliPhysiologyLarge familyMutationsProgression
2006
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents. Cell 2006, 124: 1269-1282. PMID: 16564016, DOI: 10.1016/j.cell.2006.02.023.Peer-Reviewed Original ResearchConceptsTRPA1-deficient miceInflammatory painEnvironmental irritantsInflammatory actionsProalgesic agentsPrimary afferent nociceptorsExcitatory ion channelPain hypersensitivityPungent irritantsAfferent nociceptorsNociceptor excitationAuditory functionThermal nociceptionNoxious coldMice exhibitChemotherapeutic agentsTRPA1PainIrritantsNociceptorsMiceSole targetMustard oilIon channelsInitial detection
2005
Pungent products from garlic activate the sensory ion channel TRPA1
Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM. Pungent products from garlic activate the sensory ion channel TRPA1. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 12248-12252. PMID: 16103371, PMCID: PMC1189336, DOI: 10.1073/pnas.0505356102.Peer-Reviewed Original ResearchConceptsSensory nerve endingsSensory neuronsNerve endingsTRPA1 channelsDiallyl disulfidePrimary sensory neuronsActivation of TRPA1Ion channel TRPA1Excitatory ion channelPain pathwaysPungent ingredientAllium familyVasorelaxant activityTRPA1Health benefitsNeuronsAllium extractsIon channelsAllicinMolecular mechanismsAllyl isothiocyanateEndingsPainVasodilationInflammation
2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427: 260-265. PMID: 14712238, DOI: 10.1038/nature02282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnkyrinsCalcium ChannelsCalcium SignalingCannabinoidsCapsaicinCarbacholCells, CulturedCloning, MolecularDronabinolHumansMustard PlantNerve Tissue ProteinsNeurons, AfferentNociceptorsOocytesPlant OilsRatsRats, Sprague-DawleyRNA, MessengerThapsigarginTransient Receptor Potential ChannelsTrigeminal GanglionTRPA1 Cation ChannelTRPC Cation ChannelsConceptsMustard oilPrimary sensory neuronsSensory nerve fibersSensory nerve endingsTRP ion channel familyExcitatory effectsNerve endingsNerve fibersIon channel familyPungent ingredientSensory neuronsTopical applicationPsychoactive componentΔ9-tetrahydrocannabinolTRP channelsMolecular targetsANKTM1Channel familyMolecular mechanismsAllyl isothiocyanatePainInflammationWidespread useCapsaicinHypersensitivity