2017
Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons
Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg F, Schwede F, Stein C, Jordt S, Brackmann M, Spahn V. Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons. European Journal Of Pain 2017, 21: 1072-1086. PMID: 28182310, PMCID: PMC5504413, DOI: 10.1002/ejp.1008.Peer-Reviewed Original ResearchConceptsAnkyrin-rich membranePKA-dependent mannerKinase DHEK-293 cellsSensitivity of TRPV1Immunoprecipitation experimentsDRG neuronsNovel modulatorRodent DRG neuronsIon channelsIon channel TRPV1Excitatory ion channelSmall-diameter dorsal root ganglion neuronsTransient receptor potential vanilloidImportant componentDorsal root ganglion neuronsPeripheral sensory neuronsMouse DRG neuronsChemical stimuliSensory neuronsCellsComplexesMembraneDirect modificationTRPV1 expression
2016
Tear gas: an epidemiological and mechanistic reassessment
Rothenberg C, Achanta S, Svendsen ER, Jordt S. Tear gas: an epidemiological and mechanistic reassessment. Annals Of The New York Academy Of Sciences 2016, 1378: 96-107. PMID: 27391380, PMCID: PMC5096012, DOI: 10.1111/nyas.13141.Peer-Reviewed Original ResearchConceptsTear gas agentsPeripheral sensory neuronsRecent epidemiological studiesIon channel TRPV1Lung injuryChronic morbidityOcular injuriesChronic painHigh riskSensory neuronsEpidemiological studiesAnimal modelsGas injuryInjuryPromising effectsMechanistic researchTRPV1Pepper sprayTRPA1Health risksTear gasRiskCivilian populationPotential inhibitorsCough
2009
Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1
Caceres A, Brackmann M, Bessac B, Cohn L, Jordt S. Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. The FASEB Journal 2009, 23: 580.10-580.10. DOI: 10.1096/fasebj.23.1_supplement.580.10.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseAirway inflammationOvalbumin-induced airway inflammationOvalbumin mouse modelAllergic airway inflammationObstructive pulmonary diseaseTRPA1-deficient miceChronic inflammatory statePeripheral sensory neuronsBronchoalveolar lavage fluidPro-inflammatory peptidesTh2-derived cytokinesIon channel TRPA1Lipid peroxidation productsAirway conditionsEosinophil infiltrationInflammatory mediatorsPulmonary diseaseNeuronal releaseAirway constrictionInflammatory stateLavage fluidVascular leakageEdema formationInflammatory process