2016
A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking
Wang S, Kim S, Cosgrove KP, Morris ED. A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking. NeuroImage 2016, 146: 701-714. PMID: 27743899, PMCID: PMC5321849, DOI: 10.1016/j.neuroimage.2016.10.019.Peer-Reviewed Original ResearchConceptsNeurotransmitter responsesCigarette smokingDrug stimuliDA releaseDA activationBolus injectionMild shorteningPET scansOptimal timingSmokingDopamine responsePET dataLp-ntPETDose limitTime courseSex differencesScansLoss of sensitivityBehavioral tasksDrugsLinear parametric neurotransmitter PETLower dose limitSuch responsesResponseStimuli
2014
Sex Differences in the Brain's Dopamine Signature of Cigarette Smoking
Cosgrove KP, Wang S, Kim SJ, McGovern E, Nabulsi N, Gao H, Labaree D, Tagare HD, Sullivan JM, Morris ED. Sex Differences in the Brain's Dopamine Signature of Cigarette Smoking. Journal Of Neuroscience 2014, 34: 16851-16855. PMID: 25505336, PMCID: PMC4261105, DOI: 10.1523/jneurosci.3661-14.2014.Peer-Reviewed Original ResearchConceptsCigarette smokingVentral striatumCigarette smoking differsEffect of smokingEarly PET studiesMesolimbic dopamine systemRight ventral striatumSex differencesDopaminergic eventsMale smokersNicotine patchCessation treatmentFemale smokersDorsal putamenDopaminergic responseBrain scanningSmoking differsDrug effectsDopamine systemSmokingNeurotransmitter releasePublic health dangerPET studiesCue reactivityWomenVoxelwise lp‐ntPET for detecting localized, transient dopamine release of unknown timing: Sensitivity Analysis and Application to Cigarette Smoking in the PET Scanner
Kim SJ, Sullivan JM, Wang S, Cosgrove KP, Morris ED. Voxelwise lp‐ntPET for detecting localized, transient dopamine release of unknown timing: Sensitivity Analysis and Application to Cigarette Smoking in the PET Scanner. Human Brain Mapping 2014, 35: 4876-4891. PMID: 24700424, PMCID: PMC4303353, DOI: 10.1002/hbm.22519.Peer-Reviewed Original Research
2013
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC, Cosgrove KP. Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking. Journal Of Visualized Experiments 2013, 50358. PMID: 23963311, PMCID: PMC4046621, DOI: 10.3791/50358.Peer-Reviewed Original ResearchConceptsStatistical stepsTime-varying parametersTime-varying functionModel parametersSpatial filterDecomposition techniqueKinetic model parametersConventional modelsSpatial noiseFluctuationsNew modelParametersAnalysis techniquesLp-ntPETModelConventional methodsStatistical comparisonMain stepsDynamic PET data