2019
General Predictors and Moderators of Depression Remission: A VAST-D Report
Zisook S, Johnson GR, Tal I, Hicks P, Chen P, Davis L, Thase M, Zhao Y, Vertrees J, Mohamed S. General Predictors and Moderators of Depression Remission: A VAST-D Report. American Journal Of Psychiatry 2019, 176: 348-357. PMID: 30947531, DOI: 10.1176/appi.ajp.2018.18091079.Peer-Reviewed Original ResearchMeSH KeywordsAdultAdverse Childhood ExperiencesAgedAged, 80 and overAntidepressive AgentsAripiprazoleBupropionDepressive Disorder, MajorDrug SubstitutionDrug Therapy, CombinationEmploymentFemaleGriefHumansLife TablesMaleMiddle AgedPrognosisQuality of LifeRemission InductionSeverity of Illness IndexSingle-Blind MethodUnited StatesUnited States Department of Veterans AffairsYoung AdultConceptsNext-step treatmentsRelease bupropionVeterans Health Administration patientsPatients' baseline featuresSingle-blind trialMajor depressive disorderDepression Outcomes studyComplicated grief symptomsAntidepressant treatmentBaseline characteristicsInitial treatmentDepression remissionDepressive disorderRemissionOutcome studiesTreatment selectionTreatment groupsHypomanic symptomsSwitching treatmentClinical imperativePositive mental healthChildhood adversityPatientsMental healthSpecific augmentation
2016
Characteristics of U.S. Veteran Patients with Major Depressive Disorder who require “next-step” treatments: A VAST-D report
Zisook S, Tal I, Weingart K, Hicks P, Davis LL, Chen P, Yoon J, Johnson GR, Vertrees JE, Rao S, Pilkinton PD, Wilcox JA, Sapra M, Iranmanesh A, Huang GD, Mohamed S. Characteristics of U.S. Veteran Patients with Major Depressive Disorder who require “next-step” treatments: A VAST-D report. Journal Of Affective Disorders 2016, 206: 232-240. PMID: 27479536, DOI: 10.1016/j.jad.2016.07.023.Peer-Reviewed Original ResearchConceptsMajor depressive disorderClinical featuresDepressive disorderNonpsychotic major depressive disorderInitial standard treatmentNon-veteran samplesU.S. veteran patientsCharacteristics of patientsSample of veteransRecent suicidal ideationPublic health imperativeLasting treatmentMDD treatmentVeteran patientsClinical onsetPsychiatric comorbidityAntidepressant trialsStandard treatmentClinical trialsDepression subtypesRecurrent depressionIndividual patientsSpecific treatmentPatientsSuicidal ideation
2010
Caregiver Burden in Alzheimer Disease: Cross-Sectional and Longitudinal Patient Correlates
Mohamed S, Rosenheck R, Lyketsos CG, Schneider LS. Caregiver Burden in Alzheimer Disease: Cross-Sectional and Longitudinal Patient Correlates. American Journal Of Geriatric Psychiatry 2010, 18: 917-927. PMID: 20808108, PMCID: PMC3972419, DOI: 10.1097/jgp.0b013e3181d5745d.Peer-Reviewed Original ResearchConceptsAlzheimer's diseasePatients' qualityCaregiver burdenCognitive statusCaregiver Distress ScaleUsual care settingsIntensity of careLower functional capabilitySix-month changesClinical Antipsychotic TrialsProbable Alzheimer's diseasePatients' cognitive statusDiagnosis of dementiaQuality of lifeBeck Depression InventoryCATIE-ADRelationship of burdenBurden InterviewAmbulatory outpatientsPatients CorrelatePharmacologic interventionsAntipsychotic TrialsTreatment outcomesDecreased burdenCare settings
2009
Veterans Affairs Intensive Case Management for Older Veterans
Mohamed S, Neale MS, Rosenheck R. Veterans Affairs Intensive Case Management for Older Veterans. American Journal Of Geriatric Psychiatry 2009, 17: 671-681. PMID: 19625784, DOI: 10.1097/jgp.0b013e3181a88340.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAgedAged, 80 and overCase ManagementCommunity Mental Health ServicesEvidence-Based PracticeFemaleHealth Services AccessibilityHumansLength of StayMaleMental DisordersMiddle AgedPsychiatric Status Rating ScalesSurveys and QuestionnairesTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsVeteransConceptsSevere mental illnessAssertive community treatmentOlder veteransIntensive case management programComorbid substance abuseNursing home placementIntensive case managementLate-onset problemsCase management programCommunity-based servicesRecovery-oriented servicesNonpsychotic illnessesYounger patientsEvidence-based practiceHospital treatmentElderly veteransTreatment outcomesFamily burdenCommunity treatmentRespite servicesMental illnessRecovery-focused servicesCase managementSubstance abuseElderly peopleUse of antipsychotics in the treatment of major depressive disorder in the U.S. Department of Veterans Affairs.
Mohamed S, Leslie DL, Rosenheck RA. Use of antipsychotics in the treatment of major depressive disorder in the U.S. Department of Veterans Affairs. The Journal Of Clinical Psychiatry 2009, 70: 906-12. PMID: 19422760, DOI: 10.4088/jcp.08m04450.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAntidepressive AgentsAntipsychotic AgentsComorbidityDepressive Disorder, MajorDose-Response Relationship, DrugDrug Therapy, CombinationDrug UtilizationFemaleHospitals, VeteransHumansMaleMiddle AgedUnited StatesUnited States Food and Drug AdministrationVeteransConceptsMajor depressive disorderTreatment of MDDAntipsychotic medicationDepressive disorderService useMental health service useVeterans Affairs patientsUse of antipsychoticsHealth service useComorbid mental illnessDrug Administration approvalLong-term safetyRecent U.S. FoodFirst antipsychoticAntipsychotic dosesAntipsychotic prescriptionsPsychiatric comorbidityComorbid schizophreniaMale genderAdministration approvalVeteran characteristicsMedicationsSchizoaffective disorderAntipsychoticsBipolar disorder
2008
Pharmacotherapy for Older Veterans Diagnosed With Posttraumatic Stress Disorder in Veterans Administration
Mohamed S, Rosenheck R. Pharmacotherapy for Older Veterans Diagnosed With Posttraumatic Stress Disorder in Veterans Administration. American Journal Of Geriatric Psychiatry 2008, 16: 804-812. PMID: 18827226, DOI: 10.1097/jgp.0b013e318173f617.Peer-Reviewed Original ResearchConceptsMental health clinicsSpecialty mental health clinicsPosttraumatic stress disorderOlder veteransHealth clinicsVeterans AdministrationPsychotropic medicationsPharmacotherapy of PTSDStress disorderDegree of undertreatmentPsychotropic medication classesMultivariable logistic regressionUse of medicationsYears of ageRelationship of ageMedication classesMedication utilizationPatients 45Medication usePsychotropic prescriptionsClinic typePrimary careElderly veteransSedative hypnoticsVA services
2007
Suicidality in middle aged and older patients with schizophrenia and depressive symptoms: relationship to functioning and Quality of Life
Kasckow J, Montross L, Golshan S, Mohamed S, Patterson T, Sollanzano E, Zisook S. Suicidality in middle aged and older patients with schizophrenia and depressive symptoms: relationship to functioning and Quality of Life. International Journal Of Geriatric Psychiatry 2007, 22: 1223-1228. PMID: 17506025, PMCID: PMC3118557, DOI: 10.1002/gps.1817.Peer-Reviewed Original ResearchConceptsQuality of lifeMedication Management Ability AssessmentDepressive symptomsQLS scoresUCSD Performance-based Skills AssessmentOlder patientsSocial Skills Performance AssessmentLeast mild degreeDSM-IV criteriaMore depressive symptomsWorse qualityMean ageISS scoreMedication managementMajor depressionMild degreeHeinrichs QualitySchizoaffective disorderPatientsPerformance-Based Skills AssessmentSignificant associationSpearman's rho correlational analysisWorse functioning