2009
Use of antipsychotics in the treatment of major depressive disorder in the U.S. Department of Veterans Affairs.
Mohamed S, Leslie DL, Rosenheck RA. Use of antipsychotics in the treatment of major depressive disorder in the U.S. Department of Veterans Affairs. The Journal Of Clinical Psychiatry 2009, 70: 906-12. PMID: 19422760, DOI: 10.4088/jcp.08m04450.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAntidepressive AgentsAntipsychotic AgentsComorbidityDepressive Disorder, MajorDose-Response Relationship, DrugDrug Therapy, CombinationDrug UtilizationFemaleHospitals, VeteransHumansMaleMiddle AgedUnited StatesUnited States Food and Drug AdministrationVeteransConceptsMajor depressive disorderTreatment of MDDAntipsychotic medicationDepressive disorderService useMental health service useVeterans Affairs patientsUse of antipsychoticsHealth service useComorbid mental illnessDrug Administration approvalLong-term safetyRecent U.S. FoodFirst antipsychoticAntipsychotic dosesAntipsychotic prescriptionsPsychiatric comorbidityComorbid schizophreniaMale genderAdministration approvalVeteran characteristicsMedicationsSchizoaffective disorderAntipsychoticsBipolar disorder
2007
Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia
Zisook S, Montross L, Kasckow J, Mohamed S, Palmer BW, Patterson TL, Golshan S, Fellows I, Lehman D, Solorzano E. Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia. American Journal Of Geriatric Psychiatry 2007, 15: 1005-1014. PMID: 18056819, DOI: 10.1097/jgp.0b013e3180a725ec.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsChronic DiseaseCitalopramComorbidityDepressionDepressive Disorder, MajorDouble-Blind MethodFemaleFollow-Up StudiesHealth StatusHumansMaleMiddle AgedPlacebosPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologySelective Serotonin Reuptake InhibitorsSuicideTreatment OutcomeConceptsSubsyndromal depressive symptomsDepressive symptomsOlder patientsClinical featuresSchizoaffective disorderNegative symptomsHamilton Depression Rating ScaleImportant clinical dimensionGeneral medical conditionsDepression Rating ScaleSpecific depressive symptomsMental functioningSubstantial morbiditySevere akathisiaMovement abnormalitiesChronic schizophreniaMedical conditionsDepression groupOverall psychopathologyIntervention studiesDepressive symptomatologyPatientsSymptomsOlder personsGeneral psychopathologySuicidality in middle aged and older patients with schizophrenia and depressive symptoms: relationship to functioning and Quality of Life
Kasckow J, Montross L, Golshan S, Mohamed S, Patterson T, Sollanzano E, Zisook S. Suicidality in middle aged and older patients with schizophrenia and depressive symptoms: relationship to functioning and Quality of Life. International Journal Of Geriatric Psychiatry 2007, 22: 1223-1228. PMID: 17506025, PMCID: PMC3118557, DOI: 10.1002/gps.1817.Peer-Reviewed Original ResearchConceptsQuality of lifeMedication Management Ability AssessmentDepressive symptomsQLS scoresUCSD Performance-based Skills AssessmentOlder patientsSocial Skills Performance AssessmentLeast mild degreeDSM-IV criteriaMore depressive symptomsWorse qualityMean ageISS scoreMedication managementMajor depressionMild degreeHeinrichs QualitySchizoaffective disorderPatientsPerformance-Based Skills AssessmentSignificant associationSpearman's rho correlational analysisWorse functioning
2005
Stability of Cognitive Performance in Older Patients With Schizophrenia: An 8-Week Test-Retest Study
Harvey PD, Palmer BW, Heaton RK, Mohamed S, Kennedy J, Brickman A. Stability of Cognitive Performance in Older Patients With Schizophrenia: An 8-Week Test-Retest Study. American Journal Of Psychiatry 2005, 162: 110-117. PMID: 15625208, DOI: 10.1176/appi.ajp.162.1.110.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAlgorithmsAmbulatory CareAntipsychotic AgentsCognition DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychometricsPsychomotor PerformanceReproducibility of ResultsSchizophreniaSchizophrenic PsychologySeverity of Illness IndexConceptsCognitive measuresCognitive performancePractice effectsComprehensive neuropsychological test batteryTest scoresReliable change index methodCognitive-enhancing medicationsNeuropsychological test batteryCognitive test scoresSignificant test-retest correlationsModest cognitive improvementTest-retest correlationsTest-retest performanceCognitive improvementTest batterySecond-generation antipsychotic medicationsTest-retest errorSchizophrenia patientsRetest studyAntipsychotic medicationAlternate formsConventional antipsychotic medicationsSchizophreniaSpurious improvementPrior studies