2016
Supported employment and education in comprehensive, integrated care for first episode psychosis: Effects on work, school, and disability income
Rosenheck R, Mueser KT, Sint K, Lin H, Lynde DW, Glynn SM, Robinson DG, Schooler NR, Marcy P, Mohamed S, Kane JM. Supported employment and education in comprehensive, integrated care for first episode psychosis: Effects on work, school, and disability income. Schizophrenia Research 2016, 182: 120-128. PMID: 27667369, DOI: 10.1016/j.schres.2016.09.024.Peer-Reviewed Original ResearchConceptsCommunity carePublic support incomeFirst episode psychosis programUsual community careGeneral estimation equation modelsFirst-episode psychosisEstimation equation modelsPsychosis programPublic support paymentsEpisode psychosisTreatment clinicsDays of participationTreatment approachesFEP participantsIntegrated careStudy participantsTreatment programEvidence effectivenessMonthly assessmentsGroup differencesIndividual PlacementDisability incomeGreater improvementGreater increaseCare
2015
Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia
Mohamed S, Rosenheck RA, Lin H, Swartz M, McEvoy J, Stroup S. Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia. The Journal Of Nervous And Mental Disease 2015, 203: 486-492. PMID: 26075840, DOI: 10.1097/nmd.0000000000000317.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcoholismAntipsychotic AgentsBenzodiazepinesChronic DiseaseComorbidityCross-Sectional StudiesDibenzothiazepinesDouble-Blind MethodFemaleHumansIllicit DrugsMaleMiddle AgedOlanzapinePerphenazinePiperazinesPsychiatric Status Rating ScalesQuetiapine FumarateRisperidoneSchizophreniaSchizophrenic PsychologySmokingSmoking PreventionSubstance-Related DisordersThiazolesYoung AdultConceptsSecond-generation antipsychotic drugsAntipsychotic drugsFirst-generation antipsychoticsSecond-generation antipsychoticsIntervention Effectiveness (CATIE) studySecondary outcome dataClinical Antipsychotic TrialsFirst-generation drugsSubstance use outcomesCigarette smokingSchizophrenia trialsChronic schizophreniaAntipsychotic TrialsOutcome dataNicotine useDrug useSecondary analysisPast weekAntipsychoticsEffectiveness studiesPatientsSubstance useUse outcomesTrialsDrugs
2014
Insight in inpatients with schizophrenia: Relationship to symptoms and neuropsychological functioning
Zhou Y, Rosenheck R, Mohamed S, Zhang J, Chang Q, Ou Y, Sun B, Ning Y, He H. Insight in inpatients with schizophrenia: Relationship to symptoms and neuropsychological functioning. Schizophrenia Research 2014, 161: 376-381. PMID: 25533592, DOI: 10.1016/j.schres.2014.12.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultChronic DiseaseCross-Sectional StudiesFemaleHumansInpatientsMalePsychiatric Status Rating ScalesRegression AnalysisSchizophreniaSchizophrenic PsychologySurveys and QuestionnairesCan Small Intensive Case Management Teams be as Effective as Large Teams?
Mohamed S. Can Small Intensive Case Management Teams be as Effective as Large Teams? Community Mental Health Journal 2014, 51: 161-164. PMID: 24821332, DOI: 10.1007/s10597-014-9730-y.Peer-Reviewed Original ResearchMeSH KeywordsCase ManagementCommunity Mental Health CentersCommunity PsychiatryHealth Services AccessibilityHealth Services Needs and DemandHumansLogistic ModelsMedically Underserved AreaMental DisordersOutcome and Process Assessment, Health CarePsychiatric Status Rating ScalesRural Health ServicesUnited StatesUnited States Department of Veterans AffairsVeteransConceptsVeterans Health AdministrationAssertive community treatment servicesOutcomes of veteransVHA administrative dataIntensive case management teamsLess symptom improvementIntensive case managementCommunity treatment servicesCase management teamSymptom improvementBaseline differencesTreatment servicesHealth AdministrationCase managementClinical needAdministrative dataEffect sizeMore staffOutcomesVeteransPotential effectivenessSmall declineStaffTeam
2012
Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression?
Dawes SE, Palmer BW, Meeks T, Golshan S, Kasckow J, Mohamed S, Zisook S. Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression? Neuropsychobiology 2012, 65: 168-172. PMID: 22456094, PMCID: PMC3701889, DOI: 10.1159/000331141.Peer-Reviewed Original ResearchConceptsSchizoaffective disorderCognitive deficitsDepression Rating Scale scoresHamilton Depression Rating ScaleFlexible-dose treatmentAntidepressant treatment responseDepression Rating ScaleTreatment of depressionMajor depressive disorderRating Scale scoresBaseline cognitive statusPlacebo groupAntidepressant medicationCurrent medicationsPlacebo augmentationFunctional disabilityCognitive composite scoreSubsyndromal depressionDepressive disorderSubsyndromal symptomsTreatment responseTreatment groupsDose treatmentScale scoreCognitive status
2011
Effect of second-generation antipsychotics on caregiver burden in Alzheimer's disease.
Mohamed S, Rosenheck R, Lyketsos CG, Kaczynski R, Sultzer DL, Schneider LS. Effect of second-generation antipsychotics on caregiver burden in Alzheimer's disease. The Journal Of Clinical Psychiatry 2011, 73: 121-8. PMID: 21939611, PMCID: PMC4040971, DOI: 10.4088/jcp.10m06574.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAlzheimer DiseaseAntipsychotic AgentsCaregiversCost of IllnessFemaleHumansMaleMental DisordersPsychiatric Status Rating ScalesQuality of LifeConceptsCaregiver Distress ScaleCaregivers of patientsSecond-generation antipsychoticsCaregiver burdenExperiences of caregiversAlzheimer's diseaseBurden InterviewDisease trialsNeuropsychiatric Inventory Caregiver Distress ScaleDistress ScaleCATIE-AD trialAtypical antipsychotic treatmentUsual care settingsAtypical antipsychotic drugsClinical Antipsychotic TrialsSymptoms of psychosisBeck Depression InventoryAD outpatientsTreat analysisAtypical antipsychoticsAntipsychotic treatmentAD patientsAntipsychotic drugsAntipsychotic TrialsCare settings
2009
Veterans Affairs Intensive Case Management for Older Veterans
Mohamed S, Neale MS, Rosenheck R. Veterans Affairs Intensive Case Management for Older Veterans. American Journal Of Geriatric Psychiatry 2009, 17: 671-681. PMID: 19625784, DOI: 10.1097/jgp.0b013e3181a88340.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAgedAged, 80 and overCase ManagementCommunity Mental Health ServicesEvidence-Based PracticeFemaleHealth Services AccessibilityHumansLength of StayMaleMental DisordersMiddle AgedPsychiatric Status Rating ScalesSurveys and QuestionnairesTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsVeteransConceptsSevere mental illnessAssertive community treatmentOlder veteransIntensive case management programComorbid substance abuseNursing home placementIntensive case managementLate-onset problemsCase management programCommunity-based servicesRecovery-oriented servicesNonpsychotic illnessesYounger patientsEvidence-based practiceHospital treatmentElderly veteransTreatment outcomesFamily burdenCommunity treatmentRespite servicesMental illnessRecovery-focused servicesCase managementSubstance abuseElderly people
2008
Insight, quality of life, and functional capacity in middle‐aged and older adults with schizophrenia
Roseman AS, Kasckow J, Fellows I, Osatuke K, Patterson TL, Mohamed S, Zisook S. Insight, quality of life, and functional capacity in middle‐aged and older adults with schizophrenia. International Journal Of Geriatric Psychiatry 2008, 23: 760-765. PMID: 18205246, PMCID: PMC3428424, DOI: 10.1002/gps.1978.Peer-Reviewed Original Research
2007
Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia
Zisook S, Montross L, Kasckow J, Mohamed S, Palmer BW, Patterson TL, Golshan S, Fellows I, Lehman D, Solorzano E. Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia. American Journal Of Geriatric Psychiatry 2007, 15: 1005-1014. PMID: 18056819, DOI: 10.1097/jgp.0b013e3180a725ec.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsChronic DiseaseCitalopramComorbidityDepressionDepressive Disorder, MajorDouble-Blind MethodFemaleFollow-Up StudiesHealth StatusHumansMaleMiddle AgedPlacebosPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologySelective Serotonin Reuptake InhibitorsSuicideTreatment OutcomeConceptsSubsyndromal depressive symptomsDepressive symptomsOlder patientsClinical featuresSchizoaffective disorderNegative symptomsHamilton Depression Rating ScaleImportant clinical dimensionGeneral medical conditionsDepression Rating ScaleSpecific depressive symptomsMental functioningSubstantial morbiditySevere akathisiaMovement abnormalitiesChronic schizophreniaMedical conditionsDepression groupOverall psychopathologyIntervention studiesDepressive symptomatologyPatientsSymptomsOlder personsGeneral psychopathologySuicidality in middle aged and older patients with schizophrenia and depressive symptoms: relationship to functioning and Quality of Life
Kasckow J, Montross L, Golshan S, Mohamed S, Patterson T, Sollanzano E, Zisook S. Suicidality in middle aged and older patients with schizophrenia and depressive symptoms: relationship to functioning and Quality of Life. International Journal Of Geriatric Psychiatry 2007, 22: 1223-1228. PMID: 17506025, PMCID: PMC3118557, DOI: 10.1002/gps.1817.Peer-Reviewed Original ResearchConceptsQuality of lifeMedication Management Ability AssessmentDepressive symptomsQLS scoresUCSD Performance-based Skills AssessmentOlder patientsSocial Skills Performance AssessmentLeast mild degreeDSM-IV criteriaMore depressive symptomsWorse qualityMean ageISS scoreMedication managementMajor depressionMild degreeHeinrichs QualitySchizoaffective disorderPatientsPerformance-Based Skills AssessmentSignificant associationSpearman's rho correlational analysisWorse functioning
2005
Review of assessment and treatment of PTSD among elderly American armed forces veterans
Owens GP, Baker DG, Kasckow J, Ciesla JA, Mohamed S. Review of assessment and treatment of PTSD among elderly American armed forces veterans. International Journal Of Geriatric Psychiatry 2005, 20: 1118-1130. PMID: 16315160, DOI: 10.1002/gps.1408.Peer-Reviewed Original ResearchMeSH KeywordsAgedAttitude to HealthComorbidityGeriatric AssessmentHumansPsychiatric Status Rating ScalesPsychotherapyStress Disorders, Post-TraumaticVeteransWarfareConceptsTreatment of PTSDPosttraumatic stress disorderElderly veteran populationVeteran populationElderly veteransPharmacological interventionsElderly combat veteransPharmacological treatment interventionsPilot databaseArmed forces veteransSupportive therapyPsychological comorbiditiesElderly populationTreatment interventionsSomatic symptomsCognitive deficitsReview of assessmentExposure therapySubstance abuseLiterature searchStress disorderYoung individualsLimited dataVeteransCombat veteransStability of Cognitive Performance in Older Patients With Schizophrenia: An 8-Week Test-Retest Study
Harvey PD, Palmer BW, Heaton RK, Mohamed S, Kennedy J, Brickman A. Stability of Cognitive Performance in Older Patients With Schizophrenia: An 8-Week Test-Retest Study. American Journal Of Psychiatry 2005, 162: 110-117. PMID: 15625208, DOI: 10.1176/appi.ajp.162.1.110.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAlgorithmsAmbulatory CareAntipsychotic AgentsCognition DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychometricsPsychomotor PerformanceReproducibility of ResultsSchizophreniaSchizophrenic PsychologySeverity of Illness IndexConceptsCognitive measuresCognitive performancePractice effectsComprehensive neuropsychological test batteryTest scoresReliable change index methodCognitive-enhancing medicationsNeuropsychological test batteryCognitive test scoresSignificant test-retest correlationsModest cognitive improvementTest-retest correlationsTest-retest performanceCognitive improvementTest batterySecond-generation antipsychotic medicationsTest-retest errorSchizophrenia patientsRetest studyAntipsychotic medicationAlternate formsConventional antipsychotic medicationsSchizophreniaSpurious improvementPrior studies
2004
Bipolar Disorder in Middle-Aged and Elderly Adults: Is Age of Onset Important?
Depp CA, Jin H, Mohamed S, Kaskow J, Moore DJ, Jeste DV. Bipolar Disorder in Middle-Aged and Elderly Adults: Is Age of Onset Important? The Journal Of Nervous And Mental Disease 2004, 192: 796-799. PMID: 15505527, DOI: 10.1097/01.nmd.0000145055.45944.d6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedBipolar DisorderCognition DisordersGeriatric AssessmentHumansMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesConceptsLate-onset groupLate-life bipolar disorderAge of onsetBipolar disorderFamily historyLate-onset bipolar disorderAge 40 yearsContinuous variablesCognitive functioningRelationship of ageOlder patientsMedication useClinical featuresCross-sectional designMedication usageMean ageDepressive symptomsOverall psychopathologyDistinct syndromeElderly adultsMeasures of psychopathologyDisordersNeuropsychological functioningAgeNeurobiological aspects
1999
Insight in Schizophrenia: Its Relationship to Measures of Executive Functions
MOHAMED S, FLEMING S, PENN D, SPAULDING W. Insight in Schizophrenia: Its Relationship to Measures of Executive Functions. The Journal Of Nervous And Mental Disease 1999, 187: 525-531. PMID: 10496507, DOI: 10.1097/00005053-199909000-00001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAwarenessChronic DiseaseFemaleFrontal LobeHealth StatusHumansMaleNeuropsychological TestsPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyWechsler ScalesConceptsExecutive functionAspects of executiveNegative symptomsChronic schizophreniaExecutive functioningNeuropsychological processesGeneral intelligenceNeuropsychological functionAssess UnawarenessGroup of individualsPoor insightMental disordersSchizophreniaUnawarenessSpecific symptomsMisattributionIndividualsPerformance measuresSymptomsMeasuresFunctioningLack of awarenessMotivationDeficitsIntelligence