2021
Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users
Mogali S, Askalsky P, Madera G, Jones JD, Comer SD. Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users. Pharmacology Biochemistry And Behavior 2021, 209: 173241. PMID: 34298029, PMCID: PMC8429209, DOI: 10.1016/j.pbb.2021.173241.Peer-Reviewed Original ResearchConceptsAnalgesic effectRecreational opioid usersReceptor-selective agonistOpioid usersPreclinical studiesAbuse liabilityNew York State Psychiatric InstituteRelease of cytokinesPositive subjective effectsTetracycline antibiotic minocyclineYears of ageDouble-blind outpatient studyPositive subjective responsesGlial activationAcute administrationCertain medicationsHuman research volunteersOutpatient studyGlial cellsNon-treatment seekingSame dosesRewarding effectsOxycodoneDrug AdministrationMinocycline
2017
Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence
Metz VE, Jones JD, Manubay J, Sullivan MA, Mogali S, Segoshi A, Madera G, Johnson KW, Comer SD. Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence. Neuropsychopharmacology 2017, 42: 1825-1832. PMID: 28393896, PMCID: PMC5520790, DOI: 10.1038/npp.2017.70.Peer-Reviewed Original ResearchConceptsEffect of ibudilastVisual analog scaleAnalgesic effectOpioid dependenceEffects of oxycodoneGlial cell activationOpioid use disorderTreatment of asthmaDrug Effects QuestionnaireRecent preclinical studiesCold pressor testNonselective phosphodiesterase inhibitorMaintenance doseOxycodone administrationAnalog scaleWithdrawal symptomsDrug likingHeroin cravingPressor testMale volunteersPreclinical studiesIbudilastPatient detoxificationUse disordersOxycodone
2015
The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users
Jones JD, Sullivan MA, Manubay JM, Mogali S, Metz VE, Ciccocioppo R, Comer SD. The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users. Physiology & Behavior 2015, 159: 33-39. PMID: 26455893, PMCID: PMC5444321, DOI: 10.1016/j.physbeh.2015.10.006.Peer-Reviewed Original ResearchConceptsEffect of pioglitazoneAbuse liabilityOpioid usersOpioid agonist effectsGood drug effectEffects of opioidsAbility of pioglitazoneActivation of PPARγPrescription opioid abusersDose-dependent increaseAddictive-like responsePositive subjective responsesMaintenance doseDaily dosesOpioid abusersOpioid receptorsPain perceptionReceptor agonistAgonist effectsDrug effectsOxycodonePioglitazoneRespiratory rateOpioidsCognitive effects
2013
Buprenorphine/naloxone as a promising therapeutic option for opioid abusing patients with chronic pain: Reduction of pain, opioid withdrawal symptoms, and abuse liability of oral oxycodone
Roux P, Sullivan MA, Cohen J, Fugon L, Jones JD, Vosburg SK, Cooper ZD, Manubay JM, Mogali S, Comer SD. Buprenorphine/naloxone as a promising therapeutic option for opioid abusing patients with chronic pain: Reduction of pain, opioid withdrawal symptoms, and abuse liability of oral oxycodone. Pain 2013, 154: 1442-1448. PMID: 23707283, PMCID: PMC3770461, DOI: 10.1016/j.pain.2013.05.004.Peer-Reviewed Original ResearchConceptsBUP/NXWithdrawal symptomsChronic painDrug choiceOral oxycodoneMaintenance doseBuprenorphine/naloxone maintenanceOpioid withdrawal symptomsReduction of painPromising therapeutic optionMore withdrawal symptomsLogistic regression analysisSelf-administer oxycodoneMann-Whitney testOxycodone doseOxycodone dosesMaintenance dosesBuprenorphine/Prescription opioidsMore painOxycodone useTherapeutic optionsClinical painInpatient studyOpioid abuse