Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users
Mogali S, Askalsky P, Madera G, Jones JD, Comer SD. Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users. Pharmacology Biochemistry And Behavior 2021, 209: 173241. PMID: 34298029, PMCID: PMC8429209, DOI: 10.1016/j.pbb.2021.173241.Peer-Reviewed Original ResearchConceptsAnalgesic effectRecreational opioid usersReceptor-selective agonistOpioid usersPreclinical studiesAbuse liabilityNew York State Psychiatric InstituteRelease of cytokinesPositive subjective effectsTetracycline antibiotic minocyclineYears of ageDouble-blind outpatient studyPositive subjective responsesGlial activationAcute administrationCertain medicationsHuman research volunteersOutpatient studyGlial cellsNon-treatment seekingSame dosesRewarding effectsOxycodoneDrug AdministrationMinocycline