The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users
Jones JD, Sullivan MA, Manubay JM, Mogali S, Metz VE, Ciccocioppo R, Comer SD. The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users. Physiology & Behavior 2015, 159: 33-39. PMID: 26455893, PMCID: PMC5444321, DOI: 10.1016/j.physbeh.2015.10.006.Peer-Reviewed Original ResearchConceptsEffect of pioglitazoneAbuse liabilityOpioid usersOpioid agonist effectsGood drug effectEffects of opioidsAbility of pioglitazoneActivation of PPARγPrescription opioid abusersDose-dependent increaseAddictive-like responsePositive subjective responsesMaintenance doseDaily dosesOpioid abusersOpioid receptorsPain perceptionReceptor agonistAgonist effectsDrug effectsOxycodonePioglitazoneRespiratory rateOpioidsCognitive effects