Buprenorphine/naloxone as a promising therapeutic option for opioid abusing patients with chronic pain: Reduction of pain, opioid withdrawal symptoms, and abuse liability of oral oxycodone
Roux P, Sullivan MA, Cohen J, Fugon L, Jones JD, Vosburg SK, Cooper ZD, Manubay JM, Mogali S, Comer SD. Buprenorphine/naloxone as a promising therapeutic option for opioid abusing patients with chronic pain: Reduction of pain, opioid withdrawal symptoms, and abuse liability of oral oxycodone. Pain 2013, 154: 1442-1448. PMID: 23707283, PMCID: PMC3770461, DOI: 10.1016/j.pain.2013.05.004.Peer-Reviewed Original ResearchConceptsBUP/NXWithdrawal symptomsChronic painDrug choiceOral oxycodoneMaintenance doseBuprenorphine/naloxone maintenanceOpioid withdrawal symptomsReduction of painPromising therapeutic optionMore withdrawal symptomsLogistic regression analysisSelf-administer oxycodoneMann-Whitney testOxycodone doseOxycodone dosesMaintenance dosesBuprenorphine/Prescription opioidsMore painOxycodone useTherapeutic optionsClinical painInpatient studyOpioid abuse