2023
Brain Networks and Adolescent Alcohol Use
Yip S, Lichenstein S, Liang Q, Chaarani B, Dager A, Pearlson G, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Garavan H. Brain Networks and Adolescent Alcohol Use. JAMA Psychiatry 2023, 80: 1131-1141. PMID: 37647053, PMCID: PMC10469292, DOI: 10.1001/jamapsychiatry.2023.2949.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestAlcohol use riskAlcohol misuseUse riskAlcohol use disorderMale adolescentsDisorders Identification TestSingle-site studyIntervention effortsWhole-brain patternsMean ageAlcohol use dataLeading causeMagnetic resonance imaging dataMAIN OUTCOMEReward-related processesHigh riskSeparate cohortUse disordersAlcohol consumptionCurrent severityAdolescent neurodevelopmentAlcohol use behaviorsAlcohol useAUDIT scores
2021
Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants
Lichenstein SD, Manco N, Cope LM, Egbo L, Garrison KA, Hardee J, Hillmer AT, Reeder K, Stern EF, Worhunsky P, Yip SW. Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants. Neuropsychopharmacology 2021, 47: 1000-1028. PMID: 34839363, PMCID: PMC8938408, DOI: 10.1038/s41386-021-01226-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdolescent cannabis usersCannabis-related harmsCannabis usersCannabis effectsAdolescent brain functionOngoing brain developmentFunctional neuroimaging studiesEffects of cannabisAdolescent brainNeuroimaging studiesNeural effectsPotential moderatorsNeural alterationsCannabis policy changesReduced perceptionSystematic reviewCannabis useCerebellar regionsAdolescenceBrain functionPreliminary evidenceFuture researchEarly interventionLong-term goalExtant literatureIdentification and Validation of Distinct Latent Neurodevelopmental Profiles in the Adolescent Brain and Cognitive Development Study
Lichenstein SD, Roos C, Kohler R, Kiluk B, Carroll KM, Worhunsky PD, Witkiewitz K, Yip SW. Identification and Validation of Distinct Latent Neurodevelopmental Profiles in the Adolescent Brain and Cognitive Development Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 7: 352-361. PMID: 33706021, PMCID: PMC8426420, DOI: 10.1016/j.bpsc.2021.02.013.Peer-Reviewed Original ResearchConceptsAdolescent brainHigher emotion regulationCognitive Development StudyDevelopment of psychopathologyFunctional magnetic resonanceLow-reward groupLatent profile analysisEmotion regulationCognitive performanceDevelopmental subgroupsNeurodevelopmental profileSubgroup of individualsHigh rewardReward groupIdentified subgroupsNeurodevelopmental modelModerate groupNeurodevelopmental disordersPsychiatric riskMore screen timeCurrent studyDevelopmental profileNeural functionDevelopment studiesScreen time
2019
Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling
Lichenstein SD, Scheinost D, Potenza MN, Carroll KM, Yip SW. Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling. Molecular Psychiatry 2019, 26: 4383-4393. PMID: 31719641, PMCID: PMC7214212, DOI: 10.1038/s41380-019-0586-y.Peer-Reviewed Original ResearchConceptsBrain statesDissociable neural substratesMultiple brain statesSubstance use outcomesHealthy comparison subjectsWhole-brain approachFMRI scanningFrontoparietal networkNeural substratesSubstance use treatmentNeural mechanismsDifferent brain statesFurther clinical relevanceDefault modeFMRI dataSubject replicationTreatment approachesReduced connectivityUse outcomesComparison subjectsNetwork strengthUse disordersSensory networksTreatment respondersSensory connectivity
2018
Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research
Moningka H, Lichenstein S, Worhunsky PD, DeVito EE, Scheinost D, Yip SW. Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research. Neuropsychopharmacology 2018, 44: 259-273. PMID: 30283002, PMCID: PMC6300537, DOI: 10.1038/s41386-018-0232-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid use disorderOpioid epidemicTreatment responseTask-based fMRI paradigmsUrgent public health problemMedication-assisted treatmentPrescription opioid usersCurrent opioid epidemicPublic health problemEvidence-based treatmentsPaucity of literatureHeroin cuesOpioid medicationsRelapse rateOpioid systemOpioid usersFuture neuroimaging studiesSignificant individual variabilityHealthcare costsWithdrawal effectsHealthy individualsHealth problemsSystematic reviewExtended abstinenceNeuroimaging studies