2024
Genes in context: path to more precise risk prediction in psychiatry?
Na P, Pietrzak R, Gelernter J. Genes in context: path to more precise risk prediction in psychiatry? The British Journal Of Psychiatry 2024, 1-2. PMID: 39422146, DOI: 10.1192/bjp.2024.151.Peer-Reviewed Original ResearchLoneliness Trajectories in U.S. Military Veterans: A 3-Year Longitudinal Study of Risk and Protective Factors
Ong A, Cintron D, Rottenberg J, Panaite V, Fischer I, Na P, Jeste D, Pietrzak R. Loneliness Trajectories in U.S. Military Veterans: A 3-Year Longitudinal Study of Risk and Protective Factors. The Journals Of Gerontology Series B 2024, gbae171. PMID: 39390809, DOI: 10.1093/geronb/gbae171.Peer-Reviewed Original ResearchGrowth mixture modelingU.S. military veteransLoneliness trajectoriesMilitary veteransLongitudinal Study of RiskNational Health and ResilienceEarly life adversitySelf-report ratingsProtective factorsWorse cognitive functionMental health concernsPhysical health outcomesHealth concernAdverse childhood experiencesRisk factorsLongitudinal cohort studyStudy of riskNationally representative samplePotential psychosocial riskPromote social connectednessSignificant public health concernVeterans StudyLife adversityThree-step regression analysisCognitive functionLongitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study
Hyatt C, Reddi P, Sharpe B, Michopoulos V, van Rooij S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, McLean S, Kessler R, Ressler K, Koenen K, Maples-Keller J. Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study. Journal Of Research In Personality 2024, 112: 104524. DOI: 10.1016/j.jrp.2024.104524.Peer-Reviewed Original ResearchImpulsive personality traitsPTSD symptomsPersonality traitsOne-year post-traumaSevere PTSD symptomsPost-traumaFactor modelNegative urgencyLow agreeablenessLow conscientiousnessTrauma exposurePersonality assessmentPTSD riskProspective linksSymptom TotalPTSDLongitudinal associationsAURORA studyIncremental predictorNeuroticismTime pointsSymptomsTraitsAgreeablenessConscientiousnessAssociation of Psychological Safety with Burnout and Intent to Leave Among Physician Faculty in New York City
de Guillebon E, He C, Akhtar S, Pietrzak R, Ripp J, Peccoralo L. Association of Psychological Safety with Burnout and Intent to Leave Among Physician Faculty in New York City. Journal Of General Internal Medicine 2024, 1-7. PMID: 39354250, DOI: 10.1007/s11606-024-09034-9.Peer-Reviewed Original ResearchPhysician facultyAssociated with lower oddsAssociated with lower scoresAmbulatory care departmentPrevalence of PSClinical faculty membersStandard deviation unit increasePsychologically safe environmentMultivariate logistic regression analysisFaculty physiciansLogistic regression analysisHealth systemSeven-itemInstitution-wide surveyLower oddsConclusionsA majorityCare departmentNew York CityBurnoutPhysiciansSafe environmentFemale genderOrganization QuestionnaireLower scoresOccupational characteristicsSexual Orientation Moderates the Association Between Health Care Utilization-Related Factors and Mental Health Service Nonutilization Among United States Military Veterans
Chang C, Fischer I, Harper K, Livingston N, Depp C, Norman S, Pietrzak R. Sexual Orientation Moderates the Association Between Health Care Utilization-Related Factors and Mental Health Service Nonutilization Among United States Military Veterans. Psychological Services 2024 PMID: 39347751, DOI: 10.1037/ser0000907.Peer-Reviewed Original ResearchHeterosexual veteransSexual minority veteransHealth careMinority veteransMilitary veteransPsychiatric needsMental health treatment utilizationNational Health and ResilienceSource of health careSexual minoritiesVA health careUnited States military veteransU.S. military veteransMental health problemsNationally representative sampleSexual orientationNon-VADifficulties ScheduleVeterans StudyTreatment utilizationInfluence utilizationRepresentative sampleHealth problemsVeteransMental treatmentGambling and Substance Use Disorders in U.S. Military Veterans: Prevalence, Clinical Characteristics, and Suicide Risk
Stefanovics E, Potenza M, Tsai J, Pietrzak R. Gambling and Substance Use Disorders in U.S. Military Veterans: Prevalence, Clinical Characteristics, and Suicide Risk. Journal Of Gambling Studies 2024, 1-21. PMID: 39342537, DOI: 10.1007/s10899-024-10359-7.Peer-Reviewed Original ResearchSubstance use disordersU.S. military veteransMental health treatmentGambling groupSUD-onlySuicide riskHealth treatmentMilitary veteransNon-suicidal self-injuryLifetime substance use disorderNational Health and ResilienceRisk of substance use disordersSUD-only groupSelf-report measuresMental health difficultiesAdverse childhood experiencesMental health burdenPast-year gamblingSelf-injurySuicidality/self-harmVeterans StudyUse disorderNicotine dependenceTrauma variablesBehavioral correlatesMulti-modal risk factors differentiate suicide attempters from ideators in military veterans with major depressive disorder
Goldstein K, Pietrzak R, Challman K, Chu K, Beck K, Brenner L, Interian A, Myers C, Shafritz K, Szeszko P, Goodman M, Haznedar M, Hazlett E. Multi-modal risk factors differentiate suicide attempters from ideators in military veterans with major depressive disorder. Journal Of Affective Disorders 2024, 369: 588-598. PMID: 39341292, DOI: 10.1016/j.jad.2024.09.149.Peer-Reviewed Original ResearchSuicide attemptsDepressive disorderGo/No-GoMilitary veteransSeverity of suicidal behaviorFractional anisotropyDecreased attentional controlUnited States military veteransDiagnosis of MDDDSM-5 diagnosisMagnetic-resonance-imagingSuicide prevention effortsDifferentiate veteransDSM-5Attentional controlSuicide attempt/sSuicidal behaviorSuicidal ideationMDDNeurocognitive assessmentHealthy control groupNeuroimaging variablesPrevention effortsIdeationSuicideThe association of perceived social support, resilience, and posttraumatic stress symptoms among coronavirus disease patients in the United States
Li J, Wisnivesky J, Gonzalez A, Feder A, Pietrzak R, Chanumolu D, Hu L, Kale M. The association of perceived social support, resilience, and posttraumatic stress symptoms among coronavirus disease patients in the United States. Journal Of Affective Disorders 2024, 368: 390-397. PMID: 39293600, DOI: 10.1016/j.jad.2024.09.091.Peer-Reviewed Original ResearchCOVID-19-related posttraumatic stress disorderPosttraumatic stress disorderPre-existing mental disordersSocial supportMental disordersPosttraumatic Stress Disorder ChecklistPosttraumatic stress disorder symptomsRisk of posttraumatic stress disorderCD-RISCPosttraumatic stress symptomsAcute careAssociation of perceived social supportMedical Outcomes Study Social Support SurveyTargeting of preventive interventionsConnor-Davidson Resilience ScalePsychological consequences of COVID-19Low social supportSocial Support SurveyMeasures of resilienceDSM-5Associated with lower oddsStress disorderStress symptomsCross-sectional designPsychological resilienceAmygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchAssociation patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaPersistent distress related to systemic racism among black veterans in the United States
Whealin J, Jegede O, Na P, Haeny A, Pietrzak R. Persistent distress related to systemic racism among black veterans in the United States. Journal Of Affective Disorders 2024, 365: 375-378. PMID: 39147153, DOI: 10.1016/j.jad.2024.08.052.Peer-Reviewed Original ResearchAdverse mental health sequelaeRisk of mental health problemsMilitary veteransIncreased risk of mental health problemsEthnic minority veteransSystemic racismMental health sequelaeMental health problemsUse of self-reportsEthnic minority populationsNationally representative sampleUS military veteransMultinomial logistic regression analysisSignificant emotional burdenStudy periodNon-veteransLogistic regression analysisEmotional burdenMinority veteransBlack veteransUS veteransHealth sequelaeBaseline assessmentHealthcare systemUS populationSuccessful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study
Shin J, Fischer I, Na P, Jeste D, Pietrzak R. Successful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2024 PMID: 39214753, DOI: 10.1016/j.jagp.2024.07.018.Peer-Reviewed Original ResearchGeneralized anxiety disorderPosttraumatic stress disorderMental disordersSomatic symptomsNational Health and ResilienceUS military veteransSuccessful agingAnxiety disordersDepressive disorderUS veteransStress disorderPromote successful agingHigher gratitudeVeterans StudyMilitary veteransInterventions targeting psychosocial factorsOne-in-fiveVeteransMDDDisordersPsychosocial factorsGratitudeNegative associationSymptomsMultivariate logistic regressionUnveiling the Structure in Mental Disorder Presentations
Spiller T, Duek O, Helmer M, Murray J, Fielstein E, Pietrzak R, von Känel R, Harpaz-Rotem I. Unveiling the Structure in Mental Disorder Presentations. JAMA Psychiatry 2024, 81 PMID: 39110437, PMCID: PMC11307158, DOI: 10.1001/jamapsychiatry.2024.2047.Peer-Reviewed Original ResearchSymptom combinationsNational Institute of Mental Health Data ArchivePosttraumatic stress disorderDiagnostic criteriaHeterogeneity of symptomsSecondary data analysisCross-sectional studyRevision of diagnostic criteriaSymptom-based definitionsDSM criteriaStress disorderSymptom heterogeneityDisorder presentationsClinical populationsMain OutcomesAssess symptomsGroup of individualsParticipantsSymptomsNational InstituteDisordersIndividualsSchizophreniaAnxietyIndividual frequenciesRole of homelessness and psychiatric disorders in suicide deaths among veterans: A four-way decomposition analysis
Beydoun H, Szymkowiak D, Pietrzak R, Beydoun M, Treadwell R, Tsai J. Role of homelessness and psychiatric disorders in suicide deaths among veterans: A four-way decomposition analysis. Psychiatry Research 2024, 340: 116120. PMID: 39121758, DOI: 10.1016/j.psychres.2024.116120.Peer-Reviewed Original ResearchMental health disordersFour-way decomposition analysisSubstance useHealth disordersPsychiatric disordersMortality riskSuicide deathsHomeless veteransVeterans AffairsSubstance use disordersU.S. Department of Veterans AffairsDepartment of Veterans AffairsPredictors of suicide deathVA healthcare systemFully-adjusted modelsMental health characteristicsEffects of homelessnessProportion of suicide deathsSuicide riskUse disorderHealth characteristicsRetrospective cohort studySuicideHealthcare systemDisordersPsychological Factors, Physical Conditions, and Functioning Among US Veterans
Fischer I, Na P, Feldman D, Krist A, Kudler H, Jeste D, Pietrzak R. Psychological Factors, Physical Conditions, and Functioning Among US Veterans. JAMA Network Open 2024, 7: e2427382. PMID: 39120905, PMCID: PMC11316230, DOI: 10.1001/jamanetworkopen.2024.27382.Peer-Reviewed Original ResearchMental Health Apps and U.S. Military Veterans: Perceived Importance and Utilization of the National Center for Posttraumatic Stress Disorder App Portfolio
Jaworski B, Ramsey K, Taylor K, Heinz A, Senti S, Mackintosh M, Rosen C, Owen J, Pietrzak R. Mental Health Apps and U.S. Military Veterans: Perceived Importance and Utilization of the National Center for Posttraumatic Stress Disorder App Portfolio. Psychological Services 2024, 21: 538-551. PMID: 37917475, DOI: 10.1037/ser0000806.Peer-Reviewed Original ResearchMental health appsPosttraumatic stress disorderU.S. veteransHealth appsStress disorderVeterans Affairs (VA) National CenterMental health treatmentLower household incomeMore mental health concernsSelf-management appMental health concernsU.S. military veteransNeeds of veteransMedical conditionsGeneral populationVeteran populationHealth treatmentWhite veteransHealth concernConsistent associationVariety of barriersHealth careMilitary veteransBlack veteransVeteransUnraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransA Brief Report of Lung Cancer Screening Utilization Before, During, and in the Later Stages of the COVID-19 Pandemic in the United States
Poghosyan H, Sarkar S, Richman I, Pietrzak R, Carter-Bawa L, Cooley M. A Brief Report of Lung Cancer Screening Utilization Before, During, and in the Later Stages of the COVID-19 Pandemic in the United States. JTO Clinical And Research Reports 2024, 5: 100705. PMID: 39282662, PMCID: PMC11402037, DOI: 10.1016/j.jtocrr.2024.100705.Peer-Reviewed Original ResearchLung cancer screeningLung cancer screening utilizationScreening utilizationBehavioral Risk Factor Surveillance SystemRates of lung cancer screeningRisk Factor Surveillance SystemScreening-eligible individualsCancer screening utilizationLung cancer burdenPopulation-based dataMultivariate logistic regressionCancer screeningCancer burdenImpact healthcareNational ratesIncreased oddsLogistic regressionNationwide effortSurveillance systemCOVID-19COVID-19 pandemicLung diseaseBrief reportNo sex differencesUnited StatesW35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders
Baldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders. Drug And Alcohol Dependence 2024, 260: 110653. DOI: 10.1016/j.drugalcdep.2023.110653.Peer-Reviewed Original Research