A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder
Barsuglia JP, Polanco M, Palmer R, Malcolm BJ, Kelmendi B, Calvey T. A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder. Progress In Brain Research 2018, 242: 121-158. PMID: 30471678, DOI: 10.1016/bs.pbr.2018.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBrainDose-Response Relationship, DrugHallucinogensHumansIbogaineMaleMethoxydimethyltryptaminesTime FactorsTomography, Emission-Computed, Single-PhotonConceptsAlcohol use disorderAnti-addictive propertiesUse disordersAlcohol useIbogaine treatmentBaseline scanResting-state protocolShort-term therapeutic outcomeModerate alcohol use disorderMild alcohol usePost-treatment SPECTPotential therapeutic effectsMystical-type experiencesMale military veteransBilateral caudate nucleusMultiple brain regionsSubstances of abuseDevelopmental traumaIbogaine hydrochlorideRight insulaBrain perfusionInpatient clinicSequential administrationTherapeutic effectNeuroimaging findings