2019
Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman Primates
Nabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker L, Jesudason C, Barth V, Navarro A, Kant N, Carson RE, Huang Y. Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman Primates. Journal Of Nuclear Medicine 2019, 60: 1147-1153. PMID: 30733324, DOI: 10.2967/jnumed.118.222034.Peer-Reviewed Original ResearchConceptsMuscarinic acetylcholine receptorsAcetylcholine receptorsNonhuman primatesM1 muscarinic acetylcholine receptorBrain time-activity curvesRich brain regionsArterial blood samplingNovel PET tracersSuitable reference regionRegional distribution volumesReference regionDevelopment of drugsBrain uptakeGlobus pallidusDistribution volume valuesNucleus accumbensBlood samplingPET scansTime-activity curvesCognitive impairmentAlzheimer's diseaseBrain regionsDistribution volumeSelective radiotracerRhesus monkeys
2018
Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates
Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y. Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chemical Neuroscience 2018, 10: 1544-1554. PMID: 30396272, PMCID: PMC6810685, DOI: 10.1021/acschemneuro.8b00526.Peer-Reviewed Original ResearchConceptsSynaptic vesicle glycoprotein 2AStandardized uptake valuePET radiotracersNonhuman primatesAlterations of synapsesC-UCBPeak standardized uptake valueVivo evaluationHigh brain uptakeNovel PET radiotracersBrain uptakeSynaptic densityExcellent radiotracerPsychiatric disordersUptake valueCingulate cortexAlzheimer's diseaseBrain disordersNovel radiotracersRhesus monkeysNeurodegenerative diseasesTissue kineticsDiseaseAttractive imaging propertiesLevetiracetam
2017
Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys
Gallezot JD, Nabulsi NB, Holden D, Lin SF, Labaree D, Ropchan J, Najafzadeh S, Donnelly DJ, Cao K, Bonacorsi S, Seiders J, Roppe J, Hayes W, Huang Y, Du S, Carson RE. Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys. Journal Of Nuclear Medicine 2017, 59: 327-333. PMID: 28864634, DOI: 10.2967/jnumed.117.195073.Peer-Reviewed Original ResearchConceptsMultilinear analysis 1Rhesus monkeysHighest organ doseLung tissue injuryLung regionsΜSv/MBqPlasma free fractionReceptor type 1Test-retest scansTest-retest variabilityVivo dissociationMolecule lysophosphatidic acidRight lung regionsML of plasmaNondisplaceable volumePulmonary fibrosisLung fibrosisVascular leakageInfusion protocolPlasma concentrationsTissue injuryDrug doseNormal healingOrgan doseType 1
2014
Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys
Gallezot J, Esterlis I, Bois F, Zheng M, Lin S, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse 2014, 68: 556-564. PMID: 25043426, PMCID: PMC4224280, DOI: 10.1002/syn.21767.Peer-Reviewed Original ResearchConceptsSynaptic acetylcholine concentrationPositron emission tomographyAcetylcholine concentrationRhesus monkeysInfusion of physostigmineSynaptic acetylcholine levelsDose-dependent reductionNicotinic acetylcholine receptorsAcetylcholine levelsBolus injectionAcetylcholine receptorsAcetylcholine dynamicsNew radioligandEmission tomographyArterial input functionAcetylcholinesterase inhibitorsRadioligandThalamusPhysostigmineDonepezilΑ4β2Promising tracerBaselineMonkeysShort scan duration
2008
Gender differences in 5HT1A receptor density and affinity measured by [18F]FPWAY and PET in juvenile rhesus monkeys
Chefer S, Spinelli S, Carson R, Jagoda E, Suomi S, Stein E. Gender differences in 5HT1A receptor density and affinity measured by [18F]FPWAY and PET in juvenile rhesus monkeys. NeuroImage 2008, 41: t147. DOI: 10.1016/j.neuroimage.2008.04.115.Peer-Reviewed Original Research
2003
Brain Uptake of the Acid Metabolites of F-18–Labeled WAY 100635 Analogs
Carson R, Wu Y, Lang L, Ma Y, Der M, Herscovitch P, Eckelman W. Brain Uptake of the Acid Metabolites of F-18–Labeled WAY 100635 Analogs. Cerebrovascular And Brain Metabolism Reviews 2003, 23: 249-260. DOI: 10.1097/00004647-200302000-00012.Peer-Reviewed Original ResearchBrain uptakePositron emission tomography studyArterial blood samplesEmission tomography studiesGray matter parametersPlasma free fractionLow specific bindingTime-activity dataBlood samplesTime-activity curvesAcid metabolitesVascular radioactivityRhesus monkeysTomography studyML/Free fractionTissue compartmentsBrainHuman dataHigh-performance liquid chromatography analysisPhysiologic modelDistribution volume VSpecific bindingDynamic positron emission tomography (PET) studiesLiquid chromatography analysis
2000
Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissures
Cohen R, Carson R, Saunders R, Doudet D. Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissures. Brain Research 2000, 879: 1-6. PMID: 11010998, DOI: 10.1016/s0006-8993(00)02528-2.Peer-Reviewed Original ResearchConceptsOpiate receptor avidityPositron emission tomographyReceptor avidityAnterior commissureCorpus callosumKappa-opiate receptor antagonistUnilateral optic tract lesionRhesus monkeysOptic tract lesionsBrain functional activitySplit animalsIpsilateral changesOptic tractTract lesionsUnilateral lesioningPosterior putamenReceptor antagonistHealthy monkeysLateral cortexOccipital cortexMedial cortexVisual deprivationEmission tomographyTransectionCommissureThe Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer
Shoaf S, Carson R, Hommer D, Williams W, Higley J, Schmall B, Herscovitch P, Eckelman W, Linnoila M. The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 244-252. PMID: 10698060, DOI: 10.1097/00004647-200002000-00004.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin synthesisOverdose of phenobarbitalBrain serotonin synthesis rateIsoflurane-anesthetized rhesus monkeysSerotonin synthesis rateBrain concentrationsSecond doseBrain samplesEmission tomographyRhesus monkeysDual administrationTryptophan uptakePatlak plotSerotoninMinimal conversionAdministrationMonkeysSynthesis rateL-tryptophanPET imagesPET dataTotal countOverdoseExternal quantification
1999
Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP
Cohen R, Carson R, Wyatt R, Doudet D. Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP. Synapse 1999, 33: 282-288. PMID: 10421709, DOI: 10.1002/(sici)1098-2396(19990915)33:4<282::aid-syn5>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBasal GangliaBrainCerebellumCerebral CortexDihydroxyphenylalanineFluorine RadioisotopesFunctional LateralityInfusions, ParenteralLimbic SystemMacaca mulattaNaltrexoneNarcotic AntagonistsOrgan SpecificityReceptors, OpioidReceptors, Opioid, kappaReceptors, Opioid, muTomography, Emission-ComputedConceptsOpiate receptor avidityPositron emission tomographyReceptor avidityKappa-opiate receptor antagonistInitial clinical manifestationBasal ganglia functionBasal ganglia circuitsParkinsonian animalsParkinsonian symptomsAnterior putamenClinical manifestationsDopamine innervationGanglia functionReceptor antagonistInternal carotidGanglia circuitsTreatment responsivenessOpiate pathwaysParkinson's diseaseNormal controlsMild lossEmission tomographyRhesus monkeysPET studiesMPTP
1998
Muscarinic Cholinergic Receptor Measurements With [18F]FP-TZTP: Control and Competition Studies
Carson R, Kiesewetter D, Jagoda E, Der M, Herscovitch P, Eckelman W. Muscarinic Cholinergic Receptor Measurements With [18F]FP-TZTP: Control and Competition Studies. Cerebrovascular And Brain Metabolism Reviews 1998, 18: 1130-1142. PMID: 9778190, DOI: 10.1097/00004647-199810000-00010.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnesthesiaAnesthetics, InhalationAnimalsBinding, CompetitiveBlood ProteinsBrainCholinesterase InhibitorsChromatography, Thin LayerFluorine RadioisotopesIsofluraneKineticsMacaca mulattaModels, NeurologicalPhysostigminePyridinesReceptors, MuscarinicThiazolesTomography, Emission-ComputedConceptsCholinergic receptorsBasal gangliaMuscarinic cholinergic receptorsPositron emission tomography studyM2 cholinergic receptorsMuscarinic cholinergic ligandEmission tomography studiesPositron emission tomographyBrain acetylcholineIntravenous infusionMuscarinic receptorsHigh AChE activityControl studyML xSubcortical regionsAlzheimer's diseaseGray matterCortical regionsEmission tomographyRhesus monkeysArterial input functionTomography studyCholinergic ligandsTracer injectionAChE activity