2024
First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding
Drake L, Wu Y, Naganawa M, Asch R, Zheng C, Najafzadeh S, Pracitto R, Lindemann M, Li S, Ropchan J, Labaree D, Emery P, Dias M, Henry S, Nabulsi N, Matuskey D, Hillmer A, Gallezot J, Carson R, Cai Z, Huang Y. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266470. PMID: 38360052, PMCID: PMC10924160, DOI: 10.2967/jnumed.123.266470.Peer-Reviewed Original ResearchFirst-in-human studyPlasma free fractionTime-activity curvesCentrum semiovaleNonhuman primate's resultsFirst-in-humanFree fractionNondisplaceable binding potentialRegional time-activity curvesLow nonspecific uptakeRegional distribution volumesHigh-resolution research tomograph scannerTest-retest reproducibilityCerebral blood flowSynaptic vesicle glycoprotein 2AHealthy volunteersArterial input functionNonspecific uptakePET imaging probeDistribution volumeSynapse densityIndividual MR imagesHighest specific bindingMR imagingPET imaging
1997
Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study.
Braun AR, Balkin TJ, Wesenten NJ, Carson RE, Varga M, Baldwin P, Selbie S, Belenky G, Herscovitch P. Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain 1997, 120: 1173-1197. PMID: 9236630, DOI: 10.1093/brain/120.7.1173.Peer-Reviewed Original ResearchConceptsSlow-wave sleepSleep-wake cycleHeteromodal association areasREM sleepBasal gangliaSensory cortexState-dependent changesAssociation cortexAssociation areasRegional cerebral blood flowRapid eye movement (REM) sleepActivity of limbicMesial temporal cortexCerebral blood flowEye movement sleepSecondary sensory cortexNormal male volunteersCharacteristics of sleepHeteromodal association cortexFrontoparietal association cortexUnimodal sensory areasREM sleep stateStages of sleepStatistical parametric mappingCentrencephalic structures
1992
PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy
Theodore W, Carson R, Andreasen P, Zametkin A, Blasberg R, Leiderman D, Rice K, Newman A, Channing M, Dunn B, Simpson N, Herscovitch P. PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy. Epilepsy Research 1992, 13: 129-139. PMID: 1334456, DOI: 10.1016/0920-1211(92)90068-5.Peer-Reviewed Original ResearchConceptsComplex partial seizuresEEG fociBasal gangliaTemporal lobeBrain regionsPotent opiate antagonistMesial temporal lobeCerebral blood flowOpiate receptor bindingEEG-video monitoringLateral temporal cortexLow specific bindingSpecific bindingPartial seizuresTime-activity dataKappa receptorsOpiate antagonistEpileptic focusHuman epilepsyFrontal cortexIndividual patientsOccipital lobeMean VTBlood flowBlood samplesDissociation of Object and Spatial Vision in Human Extrastriate Cortex: Age-Related Changes in Activation of Regional Cerebral Blood Flow Measured with [15 O]Water and Positron Emission Tomography
Grady C, Haxby J, Horwitz B, Schapiro M, Rapoport S, Ungerleider L, Mishkin M, Carson R, Herscovitch P. Dissociation of Object and Spatial Vision in Human Extrastriate Cortex: Age-Related Changes in Activation of Regional Cerebral Blood Flow Measured with [15 O]Water and Positron Emission Tomography. Journal Of Cognitive Neuroscience 1992, 4: 23-34. PMID: 23967855, DOI: 10.1162/jocn.1992.4.1.23.Peer-Reviewed Original ResearchRegional cerebral blood flowCerebral blood flowSuperior parietal cortexOlder subjectsParietal cortexBlood flowYoung subjectsPositron emission tomographic scansDissociation of ObjectOccipitotemporal cortexOlder male subjectsVisual cortical areasMore activationHuman extrastriate cortexPositron emission tomographyAge-related reductionAge-related changesTomographic scanCortical areasBrain areasMale subjectsVisual pathwayEmission tomographyExtrastriate cortexCortex
1991
Dissociation of object and spatial visual processing pathways in human extrastriate cortex.
Haxby JV, Grady CL, Horwitz B, Ungerleider LG, Mishkin M, Carson RE, Herscovitch P, Schapiro MB, Rapoport SI. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 1621-1625. PMID: 2000370, PMCID: PMC51076, DOI: 10.1073/pnas.88.5.1621.Peer-Reviewed Original ResearchConceptsExtrastriate cortexRegional cerebral blood flowDissociation of ObjectPrimate extrastriate cortexCerebral blood flowHealthy young menExtrastriate visual pathwaysHuman extrastriate cortexPositron emission tomographyAnterior temporal cortexSuperior parietal cortexLateral occipital cortexNew cortical areasSensorimotor control taskVisual extrastriate cortexBolus injectionOccipital cortexBlood flowCortical areasTemporal cortexNeuroanatomical locationVisual pathwayParietal cortexVisual processing pathwayEmission tomography
1983
Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and 15O-Water
Huang S, Carson RE, Hoffman EJ, Carson J, MacDonald N, Barrio JR, Phelps ME. Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and 15O-Water. Cerebrovascular And Brain Metabolism Reviews 1983, 3: 141-153. PMID: 6601663, DOI: 10.1038/jcbfm.1983.21.Peer-Reviewed Original Research