Featured Publications
Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption
Bond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption. Journal Of Neuroscience 2020, 40: 4727-4738. PMID: 32354856, PMCID: PMC7294796, DOI: 10.1523/jneurosci.3054-18.2020.Peer-Reviewed Original ResearchConceptsControl food intakeNAc projectionsFood intakeAccumbens projectionsLateral hypothalamusMesolimbic circuitsFood consumptionNucleus accumbens projectionsFood-seeking behaviorNAC controlVTA pathwayInhibitory projectionsMale miceNAc shellOptogenetic activationFiber photometryOptogenetic inhibitionPermissive rolePharmacological studiesDrug rewardVTAConsummatory behaviorIntakeAdaptive inhibitionNeural activity
2016
Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake
Zhu X, Ottenheimer D, DiLeone RJ. Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake. Frontiers In Behavioral Neuroscience 2016, 10: 66. PMID: 27147989, PMCID: PMC4828436, DOI: 10.3389/fnbeh.2016.00066.Peer-Reviewed Original ResearchD2 neuronsFood intakeEnergy intakeExcessive energy intakeNeuronal manipulationInhibition of D1Expressing NeuronsD2 receptorsDesigner receptorsD1 neuronsNucleus accumbensDopamine pathwayNeuron inhibitionWeight controlLocomotor activityBrain regionsDrug strategiesWeight gainBehavioral effectsNeuronsIntakeWheel runningEnergy expenditureReward behaviorNeural activity
2014
Optogenetic inhibition of neurons by internal light production
Land BB, Brayton CE, Furman KE, LaPalombara Z, DiLeone RJ. Optogenetic inhibition of neurons by internal light production. Frontiers In Behavioral Neuroscience 2014, 8: 108. PMID: 24744708, PMCID: PMC3978322, DOI: 10.3389/fnbeh.2014.00108.Peer-Reviewed Original ResearchOptogenetic inhibitionAmphetamine-induced locomotor activityNeural activityLuciferase-expressing virusesSuppress neural activitySpecific molecular pathwaysAdeno-associated virusLuciferase miceNeuronal activityLocomotor activityNeural circuitsActivation/inhibitionAdministrationMolecular pathwaysFos activityDelivery of lightVivo optogeneticsInhibitionMiceAnimalsVirusLuciferaseOptogeneticsOptical fiberStriatum