Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.
Raz N, Torres I, Briggs S, Spencer W, Thornton A, Loken W, Gunning F, McQuain J, Driesen N, Acker J. Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry. Neurology 1995, 45: 356-66. PMID: 7854539, DOI: 10.1212/wnl.45.2.356.Peer-Reviewed Original ResearchConceptsDS subjectsDown syndromeNeuroanatomic abnormalitiesParahippocampal gyrusWhite matterBrain regionsSex-matched healthy volunteersDisease hypothesisAnterior cingulate gyrusParietal white matterPrefrontal white matterPremature agingDorsolateral prefrontal cortexCerebral damageThyroid dysfunctionAge-related declineSeizure disorderSignificant group differencesBasal gangliaBrain abnormalitiesCardiovascular diseaseMammillary bodiesCerebellar hemispherePostcentral gyrusCingulate gyrus