A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain
Raval NR, Johansen A, Donovan LL, Ros NF, Ozenne B, Hansen HD, Knudsen GM. A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain. International Journal Of Molecular Sciences 2021, 22: 835. PMID: 33467676, PMCID: PMC7830000, DOI: 10.3390/ijms22020835.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsAutoradiographyBrainFemaleHallucinogensHippocampusLigandsPrefrontal CortexPsilocybinReceptor, Serotonin, 5-HT2ASwineSynapsesConceptsAntidepressive effectsR densitySingle dosePig brainSerotonin 2A receptor agonistSynaptic vesicle protein 2AAntidepressant effectsAntidepressive actionReceptor agonistAcute decreaseSynaptic densityReceptor densityCortex sectionsAwake pigsHippocampusDoseProtein 2ASynaptogenesisBrainPsilocybinPigsDaysAgonistsRadioligand