Pretargeted imaging beyond the blood–brain barrier
Shalgunov V, van den Broek S, Andersen I, Vázquez R, Raval N, Palner M, Mori Y, Schäfer G, Herrmann B, Mikula H, Beschorner N, Nedergaard M, Syvänen S, Barz M, Knudsen G, Battisti U, Herth M. Pretargeted imaging beyond the blood–brain barrier. RSC Medicinal Chemistry 2023, 14: 444-453. PMID: 36970152, PMCID: PMC10034008, DOI: 10.1039/d2md00360k.Peer-Reviewed Original ResearchRational drug design approachDrug design approachBioorthogonal chemistryTetrazine ligationAttractive reactionPhysicochemical propertiesFluorine-18Blood-brain barrierLead compoundsMolecular imaging technologySoluble oligomersPositron emission tomographyBiomarker proteinsIdeal radionuclideTetrazineChemistryFavorable characteristicsDrug developmentOligomersPropertiesPretargetingNanomedicineCompoundsStructureReaction