2015
Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia
Jadi MP, Behrens MM, Sejnowski TJ. Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia. Biological Psychiatry 2015, 79: 716-726. PMID: 26281716, PMCID: PMC4720598, DOI: 10.1016/j.biopsych.2015.07.005.Peer-Reviewed Original ResearchConceptsInhibitory neuronsGamma-band oscillationsNMDAR hypofunctionAnimal modelsN-methyl-D-aspartate (NMDA) receptor hypofunctionParvalbumin-expressing inhibitory neuronsAbnormal gamma oscillationsReceptor hypofunctionNMDAR antagonistsHypofunctionVisual cortexSZ symptomsSchizophreniaGamma oscillationsGenetic knockoutHuman subjectsBand oscillationsSymptomsNeuronsMagnetoencephalography (MEG) signalsPatientsAntagonistN-methylCortexNeuropharmacology
2014
An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites
Jadi MP, Behabadi BF, Poleg-Polsky A, Schiller J, Mel BW. An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites. Proceedings Of The IEEE 2014, 102: 782-798. PMID: 25554708, PMCID: PMC4279447, DOI: 10.1109/jproc.2014.2312671.Peer-Reviewed Original ResearchCortical oscillations arise from contextual interactions that regulate sparse coding
Jadi MP, Sejnowski TJ. Cortical oscillations arise from contextual interactions that regulate sparse coding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 6780-6785. PMID: 24742427, PMCID: PMC4020078, DOI: 10.1073/pnas.1405300111.Peer-Reviewed Original ResearchConceptsInhibitory neuronsFiring ratePower of oscillationsMonosynaptic inputDisynaptic pathwayHigher firing ratesLow firing ratesDisynaptic inputCortical circuitsSynaptic plasticityCortical stateCortical oscillationsModel cortical circuitSensory stimuliBehavioral statesStimulationSensory inputComplex natural stimuliInhibitory controlCortexNeuronsSpike timingActivity balanceNatural stimuliParadoxical experimental findings
2012
Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites
Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW. Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002599. PMID: 22829759, PMCID: PMC3400572, DOI: 10.1371/journal.pcbi.1002599.Peer-Reviewed Original ResearchConceptsExcitatory synaptic contactsPyramidal neuronsSynaptic contactsSpike thresholdExcitatory synaptic interactionsBasal dendritic arborsNeocortical pyramidal neuronsMore proximal inputsBasal dendritesExcitatory pathwaysDendritic arborsDistal excitationBrain slicesSynaptic projectionsSynaptic interactionsElectrophysiological recordingsProximal inputsResponse modulationFunctional asymmetryNeuronsPeak responseSomaDistal endPN responsesDendritesLocation-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites
Jadi M, Polsky A, Schiller J, Mel BW. Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002550. PMID: 22719240, PMCID: PMC3375251, DOI: 10.1371/journal.pcbi.1002550.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalcium SignalingComputational BiologyComputer SimulationDendritesExcitatory Postsynaptic PotentialsGamma-Aminobutyric AcidIn Vitro TechniquesMaleModels, NeurologicalN-MethylaspartatePyramidal CellsRatsRats, WistarSomatosensory CortexConceptsPyramidal neuronsDendritic inhibitionInterneuron typesDendritic spikesLayer 5 pyramidal neuronsSpike thresholdDistal dendritic inhibitionInhibitory interneuron typesSpike initiation zoneDendritic spike thresholdDifferent neural pathwaysBasal dendritesSynaptic contactsNeocortical slicesCortical circuitsDendritic responsesNeural pathwaysSomatic inhibitionLocal spikingSpike generationCortical computationRelative activationInhibitionDetailed compartmental modelNeurons