Featured Publications
Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance
Hampson M, Driesen N, Roth JK, Gore JC, Constable RT. Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance. Magnetic Resonance Imaging 2010, 28: 1051-1057. PMID: 20409665, PMCID: PMC2936669, DOI: 10.1016/j.mri.2010.03.021.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexCognitive tasksBrain areasCognitive functionPrefrontal cortexTask-negative regionsWhole-brain correlationMedial frontal cortexAnterior cingulate cortexGroup-level analysisMemory performanceFunctional brainCingulate cortexFunctional connectivityFrontal cortexFunctional connectionsCortexTaskRelationshipNegative correlationValidityConnectivityBrainFindingsRegressionBrain Connectivity Related to Working Memory Performance
Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT. Brain Connectivity Related to Working Memory Performance. Journal Of Neuroscience 2006, 26: 13338-13343. PMID: 17182784, PMCID: PMC2677699, DOI: 10.1523/jneurosci.3408-06.2006.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory taskCognitive tasksCingulate cortexVentral anterior cingulate cortexDifferent cognitive tasksMedial frontal regionsMedial frontal gyrusDefault mode networkAnterior cingulate cortexFunctional imaging studiesCognitive abilitiesIndividual differencesMemory performanceCognitive performanceFrontal gyrusMode networkFrontal regionsFunctional connectivityBrain connectivityBrain areasTaskFunctional connectionsImaging studiesCortexDetection of functional connectivity using temporal correlations in MR images
Hampson M, Peterson BS, Skudlarski P, Gatenby JC, Gore JC. Detection of functional connectivity using temporal correlations in MR images. Human Brain Mapping 2002, 15: 247-262. PMID: 11835612, PMCID: PMC6872035, DOI: 10.1002/hbm.10022.Peer-Reviewed Original ResearchOrbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity
Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.Peer-Reviewed Original ResearchConceptsResting-state connectivityContamination anxietyBrain regionsNF trainingBrain connectivityResting-state functional connectivityFunctional magnetic resonance imaging (fMRI) neurofeedbackPotential of neurofeedbackRelevant brain networksResting-state fMRIDorsolateral prefrontal cortexTarget brain regionsBrain functional architectureUseful therapyLimbic circuitryMatched subjectsOrbitofrontal regionsOrbitofrontal cortexFunctional connectivityPrefrontal cortexHuman emotionsFeedback control tasksSubclinical anxietyAnxiety regulationBrain networks
2021
Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior
Sukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulateFunctional connectivityAnterior cingulateDorsolateral prefrontal cortical regionsResting-state brain connectivityAggressive behaviorResting-state functional connectivityIntrinsic connectivity distributionAmygdala-prefrontal circuitryAnterior cingulate cortexIntrinsic functional connectivityPrefrontal cortical regionsHealthy controlsAmygdala connectivityGreater severityVentromedial prefrontal cortexCingulate cortexFunctional MRI dataCortical regionsMedial prefrontalMaladaptive aggressionPrefrontal cortexBrain connectivitySeverity of aggressionTreatment-seeking children
2020
Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist)
Ros T, Enriquez-Geppert S, Zotev V, Young KD, Wood G, Whitfield-Gabrieli S, Wan F, Vuilleumier P, Vialatte F, Van De Ville D, Todder D, Surmeli T, Sulzer JS, Strehl U, Sterman MB, Steiner NJ, Sorger B, Soekadar SR, Sitaram R, Sherlin LH, Schönenberg M, Scharnowski F, Schabus M, Rubia K, Rosa A, Reiner M, Pineda JA, Paret C, Ossadtchi A, Nicholson AA, Nan W, Minguez J, Micoulaud-Franchi JA, Mehler DMA, Lührs M, Lubar J, Lotte F, Linden DEJ, Lewis-Peacock JA, Lebedev MA, Lanius RA, Kübler A, Kranczioch C, Koush Y, Konicar L, Kohl SH, Kober SE, Klados MA, Jeunet C, Janssen TWP, Huster RJ, Hoedlmoser K, Hirshberg LM, Heunis S, Hendler T, Hampson M, Guggisberg AG, Guggenberger R, Gruzelier JH, Göbel RW, Gninenko N, Gharabaghi A, Frewen P, Fovet T, Fernández T, Escolano C, Ehlis AC, Drechsler R, deCharms R, Debener S, De Ridder D, Davelaar EJ, Congedo M, Cavazza M, Breteler MHM, Brandeis D, Bodurka J, Birbaumer N, Bazanova OM, Barth B, Bamidis PD, Auer T, Arns M, Thibault RT. Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist). Brain 2020, 143: 1674-1685. PMID: 32176800, PMCID: PMC7296848, DOI: 10.1093/brain/awaa009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConnectome-based neurofeedback: A pilot study to improve sustained attention
Scheinost D, Hsu TW, Avery EW, Hampson M, Constable RT, Chun MM, Rosenberg MD. Connectome-based neurofeedback: A pilot study to improve sustained attention. NeuroImage 2020, 212: 116684. PMID: 32114151, PMCID: PMC7165055, DOI: 10.1016/j.neuroimage.2020.116684.Peer-Reviewed Original ResearchConceptsFunctional connectivityRt-fMRIReal-time functional magnetic resonance imaging (rt-fMRI) neurofeedbackWhole-brain functional connectivityClinical trial designFunctional magnetic resonance imaging (fMRI) neurofeedbackDistinct brain areasConnectome-based modelsClinical symptomsTrial designBrain areasBrain regionsSustained attentionTherapeutic toolPilot studyBrain activityFunctional connectionsSymptomsNeurofeedbackFunctional networksTraining durationAttention taskComplex functional networksPilot sample
2019
Effect of deactivation of activity patterns related to smoking cue reactivity on nicotine addiction
Bu J, Young KD, Hong W, Ma R, Song H, Wang Y, Zhang W, Hampson M, Hendler T, Zhang X. Effect of deactivation of activity patterns related to smoking cue reactivity on nicotine addiction. Brain 2019, 142: 1827-1841. PMID: 31135053, DOI: 10.1093/brain/awz114.Peer-Reviewed Original ResearchConceptsSmoking cue reactivityReal-feedback groupBrain activity patternsCue reactivityEEG activity patternsCigarette cravingNicotine addictionSmoking behaviorNumber of cigarettesGold Standard ProgrammeRates of cigaretteNovel therapeutic approachesNicotine-dependent participantsNeurofeedback protocolActivity patternsSmoking amountCigarette smokingSmoking cessationClinical trialsSmoking cuesLong-term effectsNeurofeedback training sessionsTherapeutic approachesTherapeutic efficacyMonths
2018
Developing image sets for inducing obsessive-compulsive checking symptoms
Brooks H, Kichuk SA, Adams TG, Koller WN, Eken HN, Rance M, Monahan S, Wasylink S, Kelmendi B, Pittenger C, Gruner P, Hampson M. Developing image sets for inducing obsessive-compulsive checking symptoms. Psychiatry Research 2018, 265: 249-255. PMID: 29763844, PMCID: PMC6063514, DOI: 10.1016/j.psychres.2018.04.035.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderProvocative imagesSymptom provocationDiagnosis of OCDClinical obsessive-compulsive disorderInduction of anxietyContextual cuesIntrusive thoughtsVisual stimuliOC symptomsCompulsive disorderDiagnostic statusAnxietyStimuliHarmful scenariosSimilar objectsGreat provocationsIndividualsSuggestive imagesProvocationQualitative patternCuesSymptomsResearch studiesFuture studiesData-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network
Scheinost D, Tokoglu F, Hampson M, Hoffman R, Constable RT. Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network. Schizophrenia Bulletin 2018, 45: 415-424. PMID: 29660081, PMCID: PMC6403094, DOI: 10.1093/schbul/sby039.Peer-Reviewed Original ResearchConceptsAuditory Hallucination Rating ScaleIntrinsic connectivity distributionAuditory verbal hallucinationsHealthy controlsFunctional connectivityLateralized connectivitySevere global health problemSeed connectivity analysesBest treatment strategyGlobal health problemWhole-brain connectivityMedial prefrontal cortexPosterior cingulate cortexDefault mode networkSuch patientsPatient groupLeft putamenTreatment strategiesPatientsActionable targetsSchizoaffective disorderCingulate cortexHealth problemsVoxel-based measurePrefrontal cortex
2017
Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder
Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology 2017, 43: 1119-1127. PMID: 28944772, PMCID: PMC5854800, DOI: 10.1038/npp.2017.229.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAnterior cingulate cortexIntrinsic functional connectivityMedial prefrontal cortexFunctional connectivityLarge-scale brain networksDepressive disorderMDD groupAnatomical covarianceBrain networksUnmedicated major depressive disorderWhole-brain intrinsic functional connectivitySystem-level disorderIntrinsic connectivity distributionRegional brain structureMultiple brain networksAltered connectivityCommon findingHealthy comparison participantsDepressive symptomsAltered volumeUnmedicated individualsLocal circuitryCingulate cortexDepressive symptomatology
2014
Sex differences in normal age trajectories of functional brain networks
Scheinost D, Finn ES, Tokoglu F, Shen X, Papademetris X, Hampson M, Constable RT. Sex differences in normal age trajectories of functional brain networks. Human Brain Mapping 2014, 36: 1524-1535. PMID: 25523617, PMCID: PMC5522589, DOI: 10.1002/hbm.22720.Peer-Reviewed Original Research
2013
Real-time fMRI links subjective experience with brain activity during focused attention
Garrison KA, Scheinost D, Worhunsky PD, Elwafi HM, Thornhill TA, Thompson E, Saron C, Desbordes G, Kober H, Hampson M, Gray JR, Constable RT, Papademetris X, Brewer JA. Real-time fMRI links subjective experience with brain activity during focused attention. NeuroImage 2013, 81: 110-118. PMID: 23684866, PMCID: PMC3729617, DOI: 10.1016/j.neuroimage.2013.05.030.Peer-Reviewed Original ResearchConceptsReal-time fMRIPosterior cingulate cortexBrain activitySubjective experienceFocused attentionCingulate cortexCognitive neuroscience researchFocused attention taskOngoing subjective experienceFeedback graphsOwn brain activityDefault mode networkAttention taskNeural processesIntrospective awarenessOngoing taskRt-fMRIAffective functionsExperienced meditatorsMode networkNovel contextNeuroscience researchMeditatorsBrain imagingObjective measures
2012
Intrinsic Brain Connectivity Related to Age in Young and Middle Aged Adults
Hampson M, Tokoglu F, Shen X, Scheinost D, Papademetris X, Constable RT. Intrinsic Brain Connectivity Related to Age in Young and Middle Aged Adults. PLOS ONE 2012, 7: e44067. PMID: 22984460, PMCID: PMC3439483, DOI: 10.1371/journal.pone.0044067.Peer-Reviewed Original ResearchConceptsDefault mode networkIntrinsic brain connectivityAge-related differencesVoxel-based measureEmotional processingRecent developmental studiesState connectivityMode networkCognitive functionBrain scienceVisual areasMiddle-aged adultsFunctional connectivityYoung adulthoodBrain connectivityIndividual tissue elementsCortical regionsDevelopmental studiesHuman brainSubcortical regionsAged adultsPrevious findingsAge-related variationsEarly growth trajectoriesNetwork measures
2011
Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia
Hoffman RE, Pittman B, Constable RT, Bhagwagar Z, Hampson M. Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia. The British Journal Of Psychiatry 2011, 198: 277-283. PMID: 21972276, PMCID: PMC3065772, DOI: 10.1192/bjp.bp.110.086835.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusAuditory verbal hallucinationsFrontal gyrusVerbal hallucinationsRegional brain activityTemporal regionsHallucination eventsBrain activityRight inferior frontal gyrusFunctional magnetic resonance imagingRight temporal activityRight posterior temporal regionPosterior temporal regionsEffects of motorNon-hallucinating patientsRight temporal regionHallucinations groupLeft temporal regionMagnetic resonance imagingTime courseCorollary dischargeGyrusVerbal imagesRegional activitySchizoaffective disorderMicrostructural and Functional Connectivity in the Developing Preterm Brain
Lubsen J, Vohr B, Myers E, Hampson M, Lacadie C, Schneider KC, Katz KH, Constable RT, Ment LR. Microstructural and Functional Connectivity in the Developing Preterm Brain. Seminars In Perinatology 2011, 35: 34-43. PMID: 21255705, PMCID: PMC3063450, DOI: 10.1053/j.semperi.2010.10.006.Peer-Reviewed Original ResearchConceptsPreterm birthPreterm brainTerm control subjectsDiffusion tensor imaging studyFunctional connectivity studiesPreterm neonatesNeurodevelopmental impairmentControl subjectsAxonal integrityImaging studiesCognitive deficitsFunctional connectivityNeural circuitryFractional anisotropyTask-based connectivityNeural connectivityBrainExhibit alterationsNeurobiological basisConnectivity studiesWidespread alterationsMicrostructural connectivityBirthChildrenAlterationsBiofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions
Hampson M, Scheinost D, Qiu M, Bhawnani J, Lacadie CM, Leckman JF, Constable RT, Papademetris X. Biofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions. Brain Connectivity 2011, 1: 91-98. PMID: 22432958, PMCID: PMC3621512, DOI: 10.1089/brain.2011.0002.Peer-Reviewed Original ResearchConceptsSupplementary motor areaReal-time functional magnetic resonanceFunctional connectivityTourette syndromeFunctional magnetic resonanceMotor areaSubcortical regionsBiofeedback sessionsState functional connectivityTic symptomsMagnetic resonance imaging dataHealthy subjectsTS patientsMagnetic resonanceBrain areasBiofeedbackFunctional magnetic resonance imaging (fMRI) dataFurther studiesSignificant increaseAberrant dynamicsSubjectsRecent studiesImaging dataSessionsPatients
2010
Elevated Functional Connectivity Along a Corticostriatal Loop and the Mechanism of Auditory/Verbal Hallucinations in Patients with Schizophrenia
Hoffman RE, Fernandez T, Pittman B, Hampson M. Elevated Functional Connectivity Along a Corticostriatal Loop and the Mechanism of Auditory/Verbal Hallucinations in Patients with Schizophrenia. Biological Psychiatry 2010, 69: 407-414. PMID: 21145042, PMCID: PMC3039042, DOI: 10.1016/j.biopsych.2010.09.050.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsAntipsychotic AgentsCerebral CortexDiagnostic and Statistical Manual of Mental DisordersFemaleFrontal LobeHallucinationsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeostriatumNeural PathwaysNeuropsychological TestsPutamenSchizophreniaSchizophrenic PsychologySocioeconomic FactorsTemporal LobeVerbal BehaviorConceptsHealthy control subjectsControl subjectsFunctional connectivityNonhallucinating patientsPatient groupInferior frontal gyrusAuditory/verbal hallucinationsCorticostriatal loopsElevated functional connectivityVerbal hallucinationsFalse discovery rate correctionFunctional magnetic resonancePatientsSubcortical regionsLeft inferior frontal gyrusSeed regionPutamenFrontal gyrusSpeech processing networkFunctional coordinationNeural activitySchizophreniaFC relativeHigh levelsHallucinationsPreterm birth results in alterations in neural connectivity at age 16 years
Mullen KM, Vohr BR, Katz KH, Schneider KC, Lacadie C, Hampson M, Makuch RW, Reiss AL, Constable RT, Ment LR. Preterm birth results in alterations in neural connectivity at age 16 years. NeuroImage 2010, 54: 2563-2570. PMID: 21073965, PMCID: PMC3020252, DOI: 10.1016/j.neuroimage.2010.11.019.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingAge 16 yearsPT subjectsBrain injuryLow birth weight preterm childrenTerm controlsUncinate fasciculusBilateral external capsuleFA valuesWeight preterm childrenNeonatal brain injuryLower fractional anisotropy valuesYears of ageBilateral uncinate fasciculusFractional anisotropy valuesRight uncinate fasciculusRight arcuate fasciculusWhite matter disorganizationAlternative neural pathwaysPreterm birthExternal capsuleInferior frontal gyrusPreterm childrenCorpus callosumHigh riskFunctional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder
Chepenik LG, Raffo M, Hampson M, Lacadie C, Wang F, Jones MM, Pittman B, Skudlarski P, Blumberg HP. Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder. Psychiatry Research 2010, 182: 207-210. PMID: 20493671, PMCID: PMC2914819, DOI: 10.1016/j.pscychresns.2010.04.002.Peer-Reviewed Original ResearchConceptsVentral prefrontal cortexBipolar disorderFunctional connectivityPrefrontal cortexState functional magnetic resonance imagingRight ventral prefrontal cortexFunctional magnetic resonance imagingMagnetic resonance imagingWhole-brain analysisTrait abnormalityResonance imagingVentral striatumHealthy participantsAmygdalaCortexDisordersNegative correlationLow frequencyDysfunctionStriatumAbnormalities