2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose
2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2017
Inhalation of Alcohol Vapor: Measurement and Implications
MacLean RR, Valentine GW, Jatlow PI, Sofuoglu M. Inhalation of Alcohol Vapor: Measurement and Implications. Alcohol Clinical And Experimental Research 2017, 41: 238-250. PMID: 28054395, PMCID: PMC6143144, DOI: 10.1111/acer.13291.Peer-Reviewed Original ResearchConceptsAlcohol inhalationAlcohol consumptionAcute alcohol exposureElevated blood alcohol concentrationsRoute of administrationOral alcohol consumptionFirst-pass metabolismAlcohol use disorderPublic health concernMeasurement of biomarkersBlood alcohol concentrationRisk of addictionPharmacodynamic profileAlcohol exposureArterial circulationOccupational exposureMeasurable biomarkersPharmacological effectsUse disordersInhalationE-cigarettesHealth concernSubjective effectsRisk of problemsGoogle Scholar
2012
Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine
Sofuoglu M, Herman AI, Nadim H, Jatlow P. Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine. Neuropsychopharmacology 2012, 37: 1509-1516. PMID: 22334123, PMCID: PMC3327855, DOI: 10.1038/npp.2011.336.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCarbon MonoxideChi-Square DistributionChromatography, High Pressure LiquidCotinineDose-Response Relationship, DrugHeart RateHumansHydrocortisoneInjections, IntravenousMaleMiddle AgedNicotineNicotinic AgonistsSingle-Blind MethodSubstance Withdrawal SyndromeTandem Mass SpectrometryTime FactorsYoung AdultConceptsHigher nicotine metabolite ratioNicotine metabolite ratioHeart rate increaseCessation treatmentNicotine clearanceOvernight abstinenceGood drug effectBlood pressure measuresDiastolic blood pressure measuresEffects of nicotinePoor treatment responseNicotine dependence scoresTreatment-seeking smokersGreater heart rate increaseIntravenous dosesNicotine patchPoor outcomeNicotine rewardDrug likingFagerstrom TestTreatment outcomesIntravenous nicotineTreatment responseCigarette cravingHeart rate