2001
Intravenous cocaine increases plasma epinephrine and norepinephrine in humans
Sofuoglu M, Nelson D, Babb D, Hatsukami D. Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. Pharmacology Biochemistry And Behavior 2001, 68: 455-459. PMID: 11325399, DOI: 10.1016/s0091-3057(01)00482-8.Peer-Reviewed Original ResearchConceptsNorepinephrine concentrationsPlasma epinephrineHeart rate changesBlood pressureCocaine injectionHuman studiesPeak plasma epinephrineSympathoadrenal system activationPlacebo-controlled studyDiastolic blood pressureSystolic blood pressureDose of cocaineMale cocaine usersPlasma norepinephrineEpinephrine levelsSympathoadrenal systemCocaine administrationIntravenous injectionSystem activationIntravenous cocaineEpinephrineConsecutive daysNorepinephrineCocaineCocaine users
2000
Predictors of cardiovascular response to smoked cocaine in humans
Sofuoglu M, Nelson D, Dudish-Poulsen S, Lexau B, Pentel P, Hatsukami D. Predictors of cardiovascular response to smoked cocaine in humans. Drug And Alcohol Dependence 2000, 57: 239-245. PMID: 10661674, DOI: 10.1016/s0376-8716(99)00055-1.Peer-Reviewed Original ResearchConceptsCardiovascular responsesHeart rateHigher baseline blood pressureLong-term cocaine useCocaine useDiminished cardiovascular responseBaseline blood pressureBlood pressure changesAfrican American raceGreater cardiovascular responseCurrent cocaine useHigher body weightCardiovascular complicationsCurrent marijuana useBlood pressureMale sexCocaine administrationCurrent cocaineAmerican raceBody weightCocaineCocaine usersMarijuana usePredictorsPressure changes
1999
Sex and Menstrual Cycle Differences in the Subjective Effects From Smoked Cocaine in Humans
Sofuoglu M, Dudish-Poulsen S, Nelson D, Pentel P, Hatsukami D. Sex and Menstrual Cycle Differences in the Subjective Effects From Smoked Cocaine in Humans. Experimental And Clinical Psychopharmacology 1999, 7: 274-283. PMID: 10472516, DOI: 10.1037/1064-1297.7.3.274.Peer-Reviewed Original ResearchEffects of phenytoin on cocaine self-administration in humans1Portions of this report were presented at the 59th Annual Scientific Meeting of the College on the Problems of Drug Dependence, Nashville, June 1997.1
Sofuoglu M, Pentel P, Bliss R, Goldman A, Hatsukami D. Effects of phenytoin on cocaine self-administration in humans1Portions of this report were presented at the 59th Annual Scientific Meeting of the College on the Problems of Drug Dependence, Nashville, June 1997.1. Drug And Alcohol Dependence 1999, 53: 273-275. PMID: 10080053, DOI: 10.1016/s0376-8716(98)00140-9.Peer-Reviewed Original ResearchConceptsEffects of phenytoinSingle oral loading doseOral loading dosePlacebo treatment groupsEffects of cocaineHuman laboratory modelLoading doseSignificant treatment effectCocaine administrationTreatment groupsDrug dependencePhenytoinPilot studyCocaineAnnual Scientific MeetingTreatment effectsSubjective responsesScientific meetingsPlacebo