2018
Old and new synthetic cannabinoids: lessons from animal models
Zanda M, Fattore L. Old and new synthetic cannabinoids: lessons from animal models. Drug Metabolism Reviews 2018, 50: 54-64. PMID: 29376443, DOI: 10.1080/03602532.2018.1430824.Peer-Reviewed Original ResearchConceptsSynthetic cannabinoidsCannabinoid agonistsAnimal models of drug addictionConditioned place preference procedureModels of drug addictionPlace preference procedureBrain reward circuitsPositive reinforcing effectsDrug-induced behaviorsSynthetic cannabinoid agonistDelta-9-tetrahydrocannabinolReinstatement modelDrug discriminationReward circuitPreference procedureSelf-administrationAbuse liabilityPsychoactive componentAbuse potentialDrug addictionPsychiatric consequencesBehavioral studiesReinforcing effectsCannabinoidPsychoactive substances
2017
Methoxetamine affects brain processing involved in emotional response in rats
Zanda M, Fadda P, Antinori S, Di Chio M, Fratta W, Chiamulera C, Fattore L. Methoxetamine affects brain processing involved in emotional response in rats. British Journal Of Pharmacology 2017, 174: 3333-3345. PMID: 28718892, PMCID: PMC5595753, DOI: 10.1111/bph.13952.Peer-Reviewed Original ResearchConceptsBehaviorally active dosesDecreased social interaction timeMotor activityMedial prefrontal cortexObsessive-compulsive traitsReduced immobility timeSocial interaction timeSelf-grooming behaviorIncreased phosphorylation of ribosomal protein S6Antidepressant effectsImmobility timePrefrontal cortexBehavioral effectsIncreased sociabilitySpatial anxietyAcute administrationBrain processesHigh dosesIncreased swimming activityEmotional responsesDissociative effectsEmotional statesIntermediate dosePsychoactive substancesMethoxetamine
2016
Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects
Zanda M, Fadda P, Chiamulera C, Fratta W, Fattore L. Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects. Behavioural Pharmacology 2016, 27: 489-496. PMID: 27128862, DOI: 10.1097/fbp.0000000000000241.Peer-Reviewed Original ResearchConceptsEffects of methoxetamineN-methyl-d-aspartate receptor antagonistic propertiesPsychoactive substancesReceptor antagonist propertiesOccurrence of adverse effectsAdverse pharmacological effectsDopamine neurotransmissionMesolimbic pathwayAntidepressant activityPreclinical dataPreclinical findingsAntagonistic propertiesLong-term effectsPharmacological effectsStimulatory effectMethoxetamineAdverse effectsKetamineLegal highsResearch chemicalsToxicological effectsPhencyclidineDopamineNeurotransmissionIncreasing number