2023
MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration
Zanda M, Saikali L, Morris P, Daws S. MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration. Advances In Drug And Alcohol Research 2023, 3: 11668. PMID: 38389822, PMCID: PMC10880771, DOI: 10.3389/adar.2023.11668.Peer-Reviewed Original ResearchHeroin self-administrationOrbitofrontal cortexSelf-administrationDays of forced abstinenceRegulating drug-seeking behaviorSucrose self-administrationDrug-seeking behaviorChronic drug exposureAdult male ratsPeripheral blood samplesHeroin infusionsHeroin seekingMolecular neuroadaptationsForced abstinenceAcute abstinenceNeurobiological consequencesOpioid heroinOpioid misuseHeroinMale ratsSelf-administeredSeeking behaviorAbstinenceBlood samplesOpioid exposureOrbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats
Zanda M, Floris G, Daws S. Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats. Translational Psychiatry 2023, 13: 117. PMID: 37031193, PMCID: PMC10082780, DOI: 10.1038/s41398-023-02423-4.Peer-Reviewed Original ResearchConceptsOpioid use disorderOrbitofrontal cortexHL animalsHeroin seekingDrug cravingSelf-administer heroinLong-term heroinMaintenance of abstinenceDrug seeking behaviorOpioid useHeroin cravingMale ratsPreclinical studiesUse disordersDrug useExposure paradigmBrain regionsAbstinence periodAbstinenceHeroinDrug cuesSeeking behaviourLow dosageCravingProteomic analysis
2021
Author Correction: Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
Zanda M, Floris G, Daws S. Author Correction: Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence. Scientific Reports 2021, 11: 23910. PMID: 34876654, PMCID: PMC8651718, DOI: 10.1038/s41598-021-03383-9.Peer-Reviewed Original Research