Physical activity during adolescence and early adulthood and breast cancer risk before age 40 years
Kehm R, Genkinger J, Knight J, Maclnnis R, Liao Y, Li S, Weideman P, Chung W, Kurian A, Colonna S, Andrulis I, Buys S, Daly M, John E, Hopper J, Terry M. Physical activity during adolescence and early adulthood and breast cancer risk before age 40 years. Cancer Epidemiology Biomarkers & Prevention 2024, of1-of9. PMID: 39404779, DOI: 10.1158/1055-9965.epi-24-0743.Peer-Reviewed Original ResearchRecreational physical activityPhysical activityStrenuous recreational physical activityAssociated with BC riskBreast cancerBreast cancer riskBC risk factorsEarly adulthoodCox proportional hazards regression modelsProportional hazards regression modelsHazards regression modelsBC riskCancer riskLowest quartileFamily cohortStudy enrollmentRisk factorsRegression modelsYoung womenStudy centersWomenAdolescentsAgeCohortAdulthoodChildhood physical activity and pubertal timing: findings from the LEGACY girls study
Kehm R, Knight J, Houghton L, McDonald J, Schwartz L, Goldberg M, Chung W, Frost C, Wei Y, Bradbury A, Keegan T, Daly M, Buys S, Andrulis I, John E, Terry M. Childhood physical activity and pubertal timing: findings from the LEGACY girls study. International Journal Of Epidemiology 2024, 53: dyad193. PMID: 38205889, PMCID: PMC10859159, DOI: 10.1093/ije/dyad193.Peer-Reviewed Original ResearchConceptsBreast cancer family historyBody mass index-for-age z-scorePhysical activityChildhood physical activityCancer family historyLEGACY Girls StudyAssociated with later menarcheParametric survival regression modelsOrganized PAMetabolic equivalentsInverse oddsEarly childhoodSociodemographic factorsEffect modificationAssociated with ageLater menarcheNorth American cohortFamily historySurvival regression modelsStudy enrollmentMiddle childhoodAmerican cohortQuestionnaire dataPotential mediatorsZ-score