2009
Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination
Radojcic V, Bezak K, Skarica M, Pletneva M, Yoshimura K, Schulick R, Luznik L. Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination. Cancer Immunology, Immunotherapy 2009, 59: 137-148. PMID: 19590872, PMCID: PMC3103867, DOI: 10.1007/s00262-009-0734-3.Peer-Reviewed Original ResearchConceptsDendritic cell homeostasisAntitumor immunityT cellsLow-dose total body irradiationTumor antigen-specific T cellsAnti-CD25 monoclonal antibodyHematopoietic stem cell supportAntigen-specific T cellsUntreated tumor-bearing animalsTumor-infiltrating DCsExpansion of TregsRegulatory T cellsStem cell supportTotal body irradiationT cell responsesLess IL-10More IL-12Tumor-bearing animalsT cell eliminationCell homeostasisDC turnoverTreg depletionImmunotherapeutic strategiesIL-10Body irradiation
2006
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
Chan C, Crafton E, Fan H, Flook J, Yoshimura K, Skarica M, Brockstedt D, Dubensky T, Stins M, Lanier L, Pardoll D, Housseau F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nature Medicine 2006, 12: 207-213. PMID: 16444266, DOI: 10.1038/nm1352.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAntigen PresentationCell Line, TumorCytotoxicity, ImmunologicDendritic CellsGene ExpressionImmunity, InnateIn Vitro TechniquesInterferonsKiller Cells, NaturalListeria monocytogenesMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred DBAMice, KnockoutMice, TransgenicOligodeoxyribonucleotidesConceptsInterferon-producing killer dendritic cellsDendritic cellsKiller dendritic cellsI interferonNK cellsAdaptive immunityAntigen-presenting cell activityMajor histocompatibility complex class IISurface major histocompatibility complex class IIHistocompatibility complex class IIClassical NK cellsPlasmacytoid dendritic cellsTarget cellsAntigen-presenting activityConventional dendritic cellsNatural killer cellsNK target cellsToll-like receptorsType I interferonNK functionLymph nodesNKG2D receptorKiller cellsCostimulatory moleculesCytolytic capacity