Host-Derived Langerhans Cells Persist after MHC-Matched Allografting Independent of Donor T Cells and Critically Influence the Alloresponses Mediated by Donor Lymphocyte Infusions
Durakovic N, Bezak K, Skarica M, Radojcic V, Fuchs E, Murphy G, Luznik L. Host-Derived Langerhans Cells Persist after MHC-Matched Allografting Independent of Donor T Cells and Critically Influence the Alloresponses Mediated by Donor Lymphocyte Infusions. The Journal Of Immunology 2006, 177: 4414-4425. PMID: 16982876, DOI: 10.4049/jimmunol.177.7.4414.Peer-Reviewed Original ResearchConceptsCutaneous lymph nodesDonor lymphocyte infusionDonor T cellsBone marrow transplantationLangerhans cellsLymphocyte infusionMarrow transplantationCell reconstitutionT cellsDendritic cell reconstitutionDonor-derived DCsHost Langerhans cellsSplenic DC subsetsTLR7 ligand imiquimodMinor histocompatibility AgT-cell reconstitutionDLI administrationHost alloresponsesHost DCsLC emigrationDC subsetsLymph nodesCostimulatory moleculesHistocompatibility AgCells persistHost Langerhans cells (LCs) can be therapeutically manipulated In vivo with imiquimod (TLR7 agonist) to augment DLI-mediated GVH and GVL reactivity
Skarica M, Radojcic V, Luznik L. Host Langerhans cells (LCs) can be therapeutically manipulated In vivo with imiquimod (TLR7 agonist) to augment DLI-mediated GVH and GVL reactivity. Transplantation And Cellular Therapy 2006, 12: 52. DOI: 10.1016/j.bbmt.2005.11.164.Peer-Reviewed Original Research