2013
Morphine dependence and withdrawal induced changes in cholinergic signaling
Neugebauer NM, Einstein EB, Lopez MB, McClure-Begley TD, Mineur YS, Picciotto MR. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology Biochemistry And Behavior 2013, 109: 77-83. PMID: 23651795, PMCID: PMC3690589, DOI: 10.1016/j.pbb.2013.04.015.Peer-Reviewed Original ResearchConceptsMedial habenulaMorphine dependenceCholinergic signalingInterpeduncular nucleusHigh-affinity nicotinic acetylcholine receptorsNicotinic acetylcholine receptor levelsEffects of cholinergicMorphine-dependent miceChronic morphine administrationAcetylcholine receptor levelsC-fos expressionC-Fos activationNicotinic acetylcholine receptorsDependent miceMorphine administrationMorphine withdrawalCholinergic drugsOpiate withdrawalCholinergic systemEpibatidine bindingReceptor levelsSomatic signsNeuronal activityAcetylcholine receptorsNAChR receptor
2007
Galanin Protects Against Behavioral and Neurochemical Correlates of Opiate Reward
Hawes JJ, Brunzell DH, Narasimhaiah R, Langel Ű, Wynick D, Picciotto MR. Galanin Protects Against Behavioral and Neurochemical Correlates of Opiate Reward. Neuropsychopharmacology 2007, 33: 1864-1873. PMID: 17957220, PMCID: PMC2504505, DOI: 10.1038/sj.npp.1301579.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBlotting, WesternBrain ChemistryConditioning, OperantCyclic AMP Response Element-Binding ProteinDose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesGalaninGenotypeMiceMice, KnockoutMorphineMorphine DependenceMotor ActivityNarcoticsRewardSignal TransductionConceptsGKO miceMorphine place preferenceOpiate rewardGalanin agonistsMorphine administrationPlace preferenceGalanin knockout miceSingle systemic injectionEndogenous negative regulatorDrugs of abuseAcute administrationNeurochemical effectsNeuropeptide galaninPeripheral injectionWithdrawal signsLocomotor activationSystemic injectionNeurochemical correlatesNucleus accumbensGalaninKnockout miceTherapeutic targetBrain areasDrug reinforcementGalnon