2016
Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex
McClure-Begley TD, Esterlis I, Stone KL, Lam TT, Grady SR, Colangelo CM, Lindstrom JM, Marks MJ, Picciotto MR. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. ENeuro 2016, 3: eneuro.0166-16.2016. PMID: 27559543, PMCID: PMC4985585, DOI: 10.1523/eneuro.0166-16.2016.Peer-Reviewed Original ResearchConceptsPutative interacting proteinsQuantitative proteomic assessmentProtein-protein interactionsTemporal cortex tissueChaperone familyMood disordersInteracting proteinProtein complexesPresynaptic neurotransmitter releaseNovel etiological mechanismsNicotine exposureProteomic assessmentProteomeNicotinic acetylcholine receptorsMouse cortexProteinHigh-affinity nAChRsΒ2 subunitCortex of miceMaintenance of smokingNew treatment targetsResult of smokingNeurotransmitter releaseAcetylcholine receptorsPrimary function
2013
Mediating Role of Stress Reactivity in the Effects of Prenatal Tobacco Exposure on Childhood Mental Health Outcomes
Park A, O’Malley S, King SL, Picciotto MR. Mediating Role of Stress Reactivity in the Effects of Prenatal Tobacco Exposure on Childhood Mental Health Outcomes. Nicotine & Tobacco Research 2013, 16: 174-185. PMID: 23990474, PMCID: PMC3880234, DOI: 10.1093/ntr/ntt131.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChild Behavior DisordersChild, PreschoolChi-Square DistributionConfounding Factors, EpidemiologicFemaleHumansLongitudinal StudiesMaleMental DisordersMothersPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsSmokingStress, PsychologicalSurveys and QuestionnairesUnited KingdomYoung AdultConceptsMental health outcomesStressful life eventsPrenatal tobacco exposureAdverse mental health outcomesStress reactivityLife eventsMothers' ratingsChildhood mental health outcomesTobacco exposureChildren's reactivityHealth outcomesMiddle childhoodEmotional problemsAvon Longitudinal StudyDifficulties QuestionnairePreschool ageAge 4Mental healthLongitudinal studyProspective population-based studyLarge prospective population-based studyPsychiatric symptomsEarly childhoodPopulation-based studyRatingsHigh-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness
Lewis AS, Picciotto MR. High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness. Psychopharmacology 2013, 229: 477-485. PMID: 23624811, PMCID: PMC3766461, DOI: 10.1007/s00213-013-3126-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCognitionHumansMental DisordersNicotineProtein TransportReceptors, NicotinicRewardSynaptic TransmissionUp-RegulationConceptsPsychiatric illnessNicotinic acetylcholine receptor expressionPre-clinical animal modelsMultiple psychiatric illnessesChronic nicotine exposureHigh-affinity nAChRsAcetylcholine receptor expressionNicotinic receptor subtypesNovel therapeutic agentsHuman psychiatric illnessCholinergic dysfunctionClinical featuresNicotine exposurePatient populationCholinergic systemNicotine intakeReceptor expressionReceptor subtypesMood disordersTobacco usePharmacological agentsAnimal modelsPsychiatric diseasesAcetylcholine receptorsIllness
1998
Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior
PICCIOTTO M, WICKMAN K. Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior. Physiological Reviews 1998, 78: 1131-1163. PMID: 9790572, DOI: 10.1152/physrev.1998.78.4.1131.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements