2024
Medial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training
Abdulla Z, Mineur Y, Crouse R, Etherington I, Yousuf H, Na J, Picciotto M. Medial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training. Neuropsychopharmacology 2024, 1-9. PMID: 39362985, DOI: 10.1038/s41386-024-02003-0.Peer-Reviewed Original ResearchMedial prefrontal cortexACh levelsInescapable stressorEscape performanceExposure to inescapable stressorsAcetylcholine signalingLearned helplessness taskLearned helplessness trainingStress-related circuitsActive avoidance taskActive avoidance testActive avoidance responseElevation of acetylcholineIncreased ACh levelsStress-related behaviorsImpaired escape performanceIncreased brain levelsTop-down controlHelplessness trainingPrefrontal cortexAvoidance taskChemogenetic inhibitionMaladaptive behaviorsAvoidance testNegative encoding
2021
Convergent Experimental Systems for Dissecting the Neurobiology of Intrusive Thought: A Road Map
Gourley S, Bonci A, Bruchas M, Flagel S, Haber S, Kalivas P, Milton A, Phillips P, Picciotto M, Seamans J. Convergent Experimental Systems for Dissecting the Neurobiology of Intrusive Thought: A Road Map. 2021, 53-76. DOI: 10.7551/mitpress/13875.003.0010.Peer-Reviewed Original ResearchIntrusive thoughtsIntrusive thinkingThought intrusionsKarl FristonMaladaptive behaviorsMost psychiatric disordersBehavioral processesSuch thoughtsUnacceptable behaviorBehavioral mechanismsW. RobbinsFuture researchRecurrent thoughtsDecision makingA. HolmesPsychiatric disordersThoughtFree willC. RobertsThinkingIndividual responsibilityPsychologyFotopoulouBanichNeuroscience