2010
The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative‐Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice
Kamens HM, Andersen J, Picciotto MR. The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative‐Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice. Alcohol Clinical And Experimental Research 2010, 34: 2053-2060. PMID: 20946306, PMCID: PMC2988947, DOI: 10.1111/j.1530-0277.2010.01301.x.Peer-Reviewed Original ResearchConceptsSedative-hypnotic effectsBaseline locomotor activityFixed-speed rotarodAlcohol abuseEthanol consumptionNicotinic acetylcholine receptor partial agonist vareniclineLocomotor activityEthanol-induced motor incoordinationAbility of vareniclineAcute ethanol injectionDuration of LORRLocomotor activity chambersEffects of vareniclineAcute ethanol administrationNew pharmacologic strategiesDowel testDuration of lossPartial agonist vareniclineEthanol-induced ataxiaBalance beamNicotinic modulationPharmacologic strategiesMotor incoordinationEthanol administrationSedative effects
2006
The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice
Rabenstein RL, Caldarone BJ, Picciotto MR. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology 2006, 189: 395-401. PMID: 17016705, DOI: 10.1007/s00213-006-0568-z.Peer-Reviewed Original ResearchConceptsAntidepressant-like effectsAntagonist mecamylamineNicotinic acetylcholine receptor activityNoncompetitive nAChR antagonist mecamylamineAntagonist dihydro-β-erythroidineΑ7 knockout miceΑ7-nAChR subunitAcetylcholine receptor activityEffects of mecamylamineNAChR antagonist mecamylamineDihydro-β-erythroidineNicotinic antagonist mecamylamineSubunit knockout miceBaseline locomotor activityDose-response studyMethodsAdult miceAntagonist hexamethoniumAntidepressant efficacyAntidepressant responseCentral nAChRsImmobility timeCholinergic transmissionSwim testMecamylamineSuspension test