2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterations
2016
Family Social Support Modifies the Relationships Between Childhood Maltreatment Severity, Economic Adversity and Postpartum Depressive Symptoms
Muzik M, Umarji R, Sexton MB, Davis MT. Family Social Support Modifies the Relationships Between Childhood Maltreatment Severity, Economic Adversity and Postpartum Depressive Symptoms. Maternal And Child Health Journal 2016, 21: 1018-1025. PMID: 28028663, PMCID: PMC5392156, DOI: 10.1007/s10995-016-2197-4.Peer-Reviewed Original ResearchConceptsPostpartum depressive symptomsCM severityDepressive symptomsSocial Support ModifiesSocial supportChildhood maltreatmentDepressive symptom severityChildhood maltreatment severityPostpartum mothersMaternal characteristicsProtective effectRisk mothersLarge effect sizesLinear regression analysisSymptom severityPostpartum psychopathologyConclusionsThis studySeverityPDS scoresLongitudinal studyChildhood abuseHierarchical linear regression analysesFamily social supportMothersRegression analysisLongitudinal suicidal ideation across 18-months postpartum in mothers with childhood maltreatment histories
Muzik M, Brier Z, Menke RA, Davis MT, Sexton MB. Longitudinal suicidal ideation across 18-months postpartum in mothers with childhood maltreatment histories. Journal Of Affective Disorders 2016, 204: 138-145. PMID: 27344623, PMCID: PMC5012909, DOI: 10.1016/j.jad.2016.06.037.Peer-Reviewed Original ResearchConceptsPostpartum suicidal ideationSuicidal ideationChildhood maltreatmentProtective factorsCM historyMaternal suicidal ideationSeverity of SIHistory of CMSample of womenChildhood maltreatment historyPostpartumFactor associationsPercentage countsMarital statusSeverityMothersRiskIdeationFamily supportHigh rateSelf-report measuresMaltreatment historyNon-clinical sampleWomenAssociation