2024
The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanolone
2023
Does Symptom-Onset Treatment With Sertraline Improve Functional Impairment for Individuals With Premenstrual Dysphoric Disorder?
Yonkers K, Altemus M, Gilstad-Hayden K, Kornstein S, Gueorguieva R. Does Symptom-Onset Treatment With Sertraline Improve Functional Impairment for Individuals With Premenstrual Dysphoric Disorder? Journal Of Clinical Psychopharmacology 2023, 43: 320-325. PMID: 37212651, PMCID: PMC10313784, DOI: 10.1097/jcp.0000000000001700.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderFunctional impairmentSymptom onsetPMDD symptomsDysphoric disorderAnger/irritabilityDaily treatmentActive treatmentFunctional outcomeClinical trialsFunctional improvementSecondary analysisCausal mediation analysisSertralineSeverity of problemsImpairmentNonsignificant direct effectDaily ratingsPlaceboTreatmentFace validitySymptomsIrritabilityDisordersSignificant indirect effect
2015
Transcranial stimulation with low voltage, pulsed alternating current enhances parasympathetic activity
Altemus M, Mari S, Banerjee S, Yang R. Transcranial stimulation with low voltage, pulsed alternating current enhances parasympathetic activity. Brain Stimulation 2015, 8: 395. DOI: 10.1016/j.brs.2015.01.263.Peer-Reviewed Original Research
2014
Cranial Electrical Stimulation
Mindes J, Dubin M, Altemus M. Cranial Electrical Stimulation. 2014, 127-150. DOI: 10.1007/978-1-4939-1408-1_11.Peer-Reviewed Original ResearchCranial electrical stimulation (CES): Comparison with cranial nerve stimulation, transcranial direct current stimulation and transcranial low voltage pulsed electromagnetic fields
Mindes J, Dubin M, Altemus M. Cranial electrical stimulation (CES): Comparison with cranial nerve stimulation, transcranial direct current stimulation and transcranial low voltage pulsed electromagnetic fields. Brain Stimulation 2014, 7: e13. DOI: 10.1016/j.brs.2014.01.047.Peer-Reviewed Original ResearchCranial electrical stimulation (CES): Barriers to acceptance and new advances
Mindes J, Dubin M, Altemus M. Cranial electrical stimulation (CES): Barriers to acceptance and new advances. Brain Stimulation 2014, 7: e13. DOI: 10.1016/j.brs.2014.01.046.Peer-Reviewed Original ResearchThyroid Function And Depression In Pregnant Women In Qatar
Nasir M, Mari S, Abdulmalik M, Sheikh J, Altemus M. Thyroid Function And Depression In Pregnant Women In Qatar. 2014 DOI: 10.5339/qfarc.2014.hbpp0646.Peer-Reviewed Original Research
2013
A sensitive and selective LC-differential mobility-mass spectrometric analysis of allopregnanolone and pregnanolone in human plasma
Jin W, Jarvis M, Star-Weinstock M, Altemus M. A sensitive and selective LC-differential mobility-mass spectrometric analysis of allopregnanolone and pregnanolone in human plasma. Analytical And Bioanalytical Chemistry 2013, 405: 9497-9508. PMID: 24121434, PMCID: PMC3984615, DOI: 10.1007/s00216-013-7391-2.Peer-Reviewed Original ResearchMS/MS detectionSimple liquid-liquid extractionLinear calibration curveHexane/ethyl acetateHuman plasmaIntra-day precisionLiquid-liquid extractionIntra-day accuracyMobility separationQuality control samplesUnderivatized compoundsMS detectionSelective methodSpectrometric analysisConcentration rangeCalibration curveEthyl acetateLower limitSeparationColumnReagentsCompoundsEpimersPlasma samplesPg/mL
2012
Chapter 52 Mental Health and Behavioral Disorders in Pregnancy
Wisner K, Sit D, Altemus M, Bogen D, Famy C, Pearlstein T, Misra D, Reynolds S, Perel J. Chapter 52 Mental Health and Behavioral Disorders in Pregnancy. 2012, 1156-1188.e2. DOI: 10.1016/b978-1-4377-1935-2.00052-1.Peer-Reviewed Original Research
2008
Antidepressant-associated changes in semen parameters
Tanrikut C, Feldman A, Altemus M, Paduch D, Schlegel P. Antidepressant-associated changes in semen parameters. Fertility And Sterility 2008, 90: s2-s3. DOI: 10.1016/j.fertnstert.2008.07.287.Peer-Reviewed Original Research
2007
CHAPTER 50 Psychiatric Disorders
Wisner K, Sit D, Reynolds S, Altemus M, Bogen D, Sunder K, Misra D, Perel J. CHAPTER 50 Psychiatric Disorders. 2007, 1249-1288. DOI: 10.1016/b978-0-443-06930-7.50052-9.Peer-Reviewed Original ResearchAssociation between frontolimbic function and cortisol levels in response to traumatic stimuli in normal subjects
Tüscher O, Root J, Pan H, Epstein J, Altemus M, Cloitre M, Silverman M, Furman D, LeDoux J, McEwen B, Stern E, Silbersweig D. Association between frontolimbic function and cortisol levels in response to traumatic stimuli in normal subjects. Aktuelle Neurologie 2007, 34 DOI: 10.1055/s-2007-987685.Peer-Reviewed Original Research
2006
Romantic Love and Sexual Desire in Close Relationships
Gonzaga G, Turner R, Keltner D, Campos B, Altemus M. Romantic Love and Sexual Desire in Close Relationships. Emotion 2006, 6: 163-179. PMID: 16768550, DOI: 10.1037/1528-3542.6.2.163.Peer-Reviewed Original ResearchThe Biological Underpinnings of Depression
Korszun A, Altemus M, Young E. The Biological Underpinnings of Depression. 2006, 41-61. DOI: 10.1017/cbo9780511841262.005.Peer-Reviewed Original ResearchAdrenocorticotropic hormoneDepressive disorderHypothalamic pituitary adrenal axisAnterior pituitary corticotropesPituitary-adrenal axisDevelopment of depressionCases of depressionStress-related conditionsGlucocorticoid feedbackPituitary siteAdrenal axisHPA axisCortisol secretionExaggerated responseAdrenal glucocorticoidsPituitary corticotropesHormonal systemsDepressionGenetic vulnerabilityComplex dynamic equilibriumBiological underpinningsCentral effectorIntroduction StressExtrinsic stressorsLife events
2005
Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle
Protopopescu X, Pan H, Altemus M, Tuescher O, Polanecsky M, McEwen B, Silbersweig D, Stern E. Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 16060-16065. PMID: 16247013, PMCID: PMC1276043, DOI: 10.1073/pnas.0502818102.Peer-Reviewed Original ResearchSynchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand
Coplan J, Altemus M, Mathew S, Smith E, Sharf B, Coplan P, Kral J, Gorman J, Owens M, Nemeroff C, Rosenblum L. Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand. CNS Spectrums 2005, 10: 530-536. PMID: 16155510, DOI: 10.1017/s109285290001018x.Peer-Reviewed Original ResearchConceptsCentral corticotropin-releasing factorCSF CRF concentrationsCRF concentrationsCentral CRF systemCorticotropin-releasing factorSignificant mean increaseCerebrospinal fluid samplesEarly life stressorsVFD conditionsInfant sex differencesEnvironment-gene interactionsCRF levelsCRF expressionPsychiatric disordersCRF responseCRF systemInfant's lifeMean increaseDays postpartumInfantsStudy periodFluid samplesMothersMaternal responsivitySex differencesSex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetinePuberty, Ovarian Steroids, and Stress
YOUNG E, ALTEMUS M. Puberty, Ovarian Steroids, and Stress. Annals Of The New York Academy Of Sciences 2004, 1021: 124-133. PMID: 15251881, DOI: 10.1196/annals.1308.013.Peer-Reviewed Original ResearchConceptsStressful life eventsMajor depressionDepressed womenPostmenopausal depressed womenReproductive hormonal changesLife eventsNormal progesteronePremenopausal womenCommon etiologyOvarian hormonesOvarian steroidsHPA axisAdrenal axisNormal womenLow estradiolFirst episodeDepressed menHormonal changesBaseline cortisolEstradiolInhibitory feedbackPubertyYoung adulthoodWomenDepression
2003
Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse
Altemus M, Cloitre M, Dhabhar F. Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse. American Journal Of Psychiatry 2003, 160: 1705-1707. PMID: 12944352, DOI: 10.1176/appi.ajp.160.9.1705.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderDelayed-type hypersensitivity (DTH) skin test responsesCircadian salivary cortisol levelsHypersensitivity skin test responsesDelayed-type hypersensitivitySkin test responsesCellular immune responsesHPA axis activityCell-mediated inflammatory reactionsHealthy comparison subjectsSalivary cortisol levelsAdrenal axisSympathoadrenomedullary systemAxis activityInflammatory reactionImmune responseImmune functionPsychiatric disordersComparison subjectsCortisol levelsPlasma cortisolHistory of abuseSingle time point measurementStress disorderTime point measurements